Functional Nanoplatforms Overcoming Immune Resistance in Skin Cancers: Targeted Immunomodulation, Immunogenic Cell Death, and Metabolic Remodeling
Engineered nanoparticles show promise overcoming immune resistance in skin cancers, with AI tailoring designs for individual tumors.
This review synthesizes advances in multifunctional nanoplatforms for overcoming immunotherapy resistance in melanoma, SCC, and Merkel cell carcinoma, covering checkpoint reprogramming, immunogenic cell death induction via novel pathways (cuproptosis), and tumor metabolic remodeling. AI-driven design and liquid biopsy-guided adaptive strategies are highlighted as emerging translational directions.
What the study was
- Study design
- Narrative/comprehensive review
- Population
- Melanoma, cutaneous SCC, Merkel cell carcinoma
- Category
- Treatment Innovation
- Maturity
- Exploratory
- Journal
- Cancer Letters
Why it surfaced
Review of preclinical nanoplatform work; broad scope covers relevant immunotherapy and AI-design topics but no new clinical data; design quality 0 for review.
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