📅 PUBMED DAILY TRIAGE — 2026-03-30

Window: 2026-03-29T09:00:00Z → 2026-03-30T09:00:00Z (CRDT) Topics scanned: 10 | Articles reviewed: ~130 raw | Articles classified: 15 High priority: 3 | Standard: 11 | Low/archive: 0 | Unsolicited finds: 1 Run status: PARTIAL_SUCCESS

🔴🟠 HIGH PRIORITY

TR-2026-03-30-001 · PMID 41905703 · Score: 9/10 · 🟠 NOVEL_TREATMENT Gene therapy for sickle cell disease: Practice recommendations from ASTCT and ISCT&GT First joint societal practice guidelines for FDA-approved SCD gene therapies (betibeglogene, lovotibeglogene autotemcel); directly actionable implementation framework for rare disease with extreme unmet need. Journal: Transplantation and Cellular Therapy | Evidence: Potentially Practice-Changing

TR-2026-03-30-002 · PMID 41904890 · Score: 8/10 · 🟠 NOVEL_TREATMENT MVI-targeted carbon-ion radiotherapy combined with immunotherapy for advanced HCC: Phase Ib DEPARTURE trial First-in-human data combining carbon-ion RT (targeting macrovascular invasion) with immunotherapy in advanced hepatocellular carcinoma — a novel modality combination with proof-of-concept safety/efficacy in a high-unmet-need setting. Journal: JHEP Reports | Evidence: Exploratory

TR-2026-03-30-003 · PMID 41905242 · Score: 8/10 · 🟡 UNDERSERVED_POPULATION Aflibercept and 5-FU vs. FOLFOX as 1st line for frail elderly patients with metastatic colorectal cancer: AIO/IKF ELDERLY trial Randomized Phase 2 trial specifically designed for frail elderly mCRC — a systematically excluded population; provides near-actionable comparative efficacy data for a very common clinical management gap. Journal: European Journal of Cancer | Evidence: Validated

🟢⚪ STANDARD

TR-2026-03-30-004 · PMID 41905276 · Score: 7/10 · Diagnostics Hematological immune-related adverse events associated with checkpoint inhibitors [Systematic Review] Crit Rev Oncol Hematol | Hematology + Immunotherapy intersection; management-focused

TR-2026-03-30-005 · PMID 41905569 · Score: 7/10 · Diagnostics / Early Detection Leukemia Diagnosis 2.0: Revolutionizing Point-of-Care Detection and Monitoring [Review] Crit Rev Oncol Hematol | AI, biosensors, microfluidics for leukemia POC; triple watchlist match

TR-2026-03-30-006 · PMID 41905260 · Score: 7/10 · Diagnostics LLMs for risk-of-bias assessment in RCTs: a comparative validation study EBioMedicine | LLM performance competitive with human reviewers; AI/ML clinical decision support

TR-2026-03-30-007 · PMID 41904616 · Score: 7/10 · Treatment Innovation Atrasentan + SGLT2 inhibitors in IgA nephropathy: Placebo-controlled crossover trial (ASSIST) JASN | RCT testing combination cardiorenal therapy beyond SGLT2i monotherapy in progressive IgAN

TR-2026-03-30-011 · PMID 41906138 · Score: 7/10 · Prevention / Public Health Social determinants of health, behavioral factors, and incident dementia: prospective cohort Alzheimer's Research & Therapy | Multi-domain modifiable risk factor evidence for dementia prevention

TR-2026-03-30-008 · PMID 41905710 · Score: 6/10 · Diagnostics / Treatment Innovation Pan-cancer computational model for predicting immunotherapy response via tumor immune activity Cancer Letters | AI + immunotherapy response biomarker; pan-cancer applicability

TR-2026-03-30-009 · PMID 41905185 · Score: 6/10 · Diagnostics AI-assisted FTIR spectroscopy for hormone receptor subtyping in breast cancer tissues Spectrochim Acta A | AI spectroscopy for IHC-alternative subtyping; resource-equity potential

TR-2026-03-30-010 · PMID 41905568 · Score: 6/10 · Treatment Innovation Chemoimmunotherapy efficacy with vs. without liver metastases: Systematic review & meta-analysis Crit Rev Oncol Hematol | Liver-met status as immunotherapy modifier; patient stratification guidance

TR-2026-03-30-012 · PMID 41905188 · Score: 6/10 · Diagnostics 🟢 Plasma GFAP outperforms CSF GFAP in detecting amyloid pathology in early Alzheimer's disease J Prev Alzheimers Dis | Blood-based AD biomarker outperforming lumbar puncture test; near-term implementable

TR-2026-03-30-013 · PMID 41905822 · Score: 6/10 · Treatment Innovation SGLT2 vs. DPP4 inhibitors added to insulin in poorly controlled T2DM: Meta-analysis Prim Care Diabetes | Comparative effectiveness meta-analysis for very common clinical decision

TR-2026-03-30-014 · PMID 41904760 · Score: 5/10 · Drug Development ⚪ Tirzepatide mitigates atherosclerosis and modulates macrophage polarization: preclinical evidence Arch Pharm Res | Tirzepatide cardiovascular mechanism; preclinical; supports GLP-1/SGLT2 watchlist

💡 UNSOLICITED FINDS

TR-2026-03-30-015 · PMID 41904963 · Score: 7/10 Serum Neurofilament Light Chain and Cardiovascular Outcomes in Atrial Fibrillation JAMA Cardiology | Neurological biomarker (NfL) translating into AFib CV risk stratification — novel biomarker crossing disciplines; prospective cohort design; not on watchlist but high signal.

📊 TODAY'S BREAKDOWN

By research category:

• Diagnostics: 7 (incl. 1 unsolicited)
• Treatment Innovation: 5
• Prevention: 1
• Drug Development: 1
• Genomics/Precision Medicine: (secondary for 2)

By evidence maturity:

• Validated: 6
• Exploratory: 6
• Potentially Practice-Changing: 1

By watchlist topic (primary match):

• Novel therapeutics (immunotherapy/CAR-T/targeted): 4
• AI/ML in clinical diagnostics: 3
• Cardiovascular-metabolic (GLP-1/SGLT2): 3
• Hematologic malignancies: 2
• Aging/longevity: 2
• Rare diseases: 1 (via hematologic/gene therapy)
• Precision oncology: 1 (secondary on multiple)
• CBC diagnostics: 0

By source type:

• Peer reviewed: 15
• Preprint: 0

By pipeline priority:

• HIGH: 3
• STANDARD: 11
• LOW: 0

🔧 RUN NOTES

• Window expansion: NOT triggered (15 classified articles, ≥5 threshold met).
• Truncation: NOT triggered for any topic.
• Partial failures:
  • Sentinel search failed with NCBI backend error ("Database is not supported"); unsolicited find (PMID 41904963) was captured via topic overlap.
  • First esummary batch (26 PMIDs from hematologic + liquid biopsy searches) returned empty — these are newly indexed records not yet retrievable via efetch. They will be available in the next run. No silent discard: PMIDs logged for deduplication.
• Hematologic malignancies note: 3 hematologic records captured via overlapping searches (41905276, 41905569, 41905911 — the last being a Japanese-language case report that was excluded). Main 17 hematologic PMIDs deferred.
• Liquid biopsy note: 6 PMIDs returned; esummary retrieval failed for fresh records. Two overlapping with immunotherapy topic. Zero distinct liquid biopsy / ctDNA articles fully classified this run.
• Previously emitted fingerprints: All 15 new articles confirmed net-new vs. 87 prior fingerprints. Zero duplicates detected.
• Data quality notes: PMID 41906138 had no "Has Abstract" attribute in esummary; content inferred from title and journal. Classification confidence set to medium.