Daily digest · Thu · 2 Apr 2026

A plain-language summary of published research — not medical advice. Talk to a clinician about your own care.

🔴🟠 HIGH PRIORITY (8+) — Best Finds by Topic

Hematologic Malignancies

PMID 41914434 · HMA+venetoclax in younger AML: Meta-analysis of a shifting treatment paradigm · 8/10 · First major meta-analysis showing 75% 1-year OS with HMA+venetoclax in younger/fit AML patients, challenging intensive chemo as sole standard.

Early Cancer Detection

PMID 41918361 · Circulating Tumor Cells as liquid biopsy for noninvasive CRC screening · 8/10 · Novel CTC-based approach to noninvasive colorectal cancer screening published in CEBP; distinct from ctDNA methods.

Precision Oncology / Genomic Medicine

PMID 41916322 · Ultra-rare functional variants reveal early-onset breast cancer risk genes (UK Biobank + All of Us) · 8/10 · Novel gene discovery for early-onset breast cancer risk using ultra-rare variant analysis across two major biobanks (AJHG).

CBC-based diagnostics: No high-priority finds today (best: 5/10)

AI/ML in diagnostics: No high-priority finds today (best: 6/10)

Novel therapeutics: No high-priority finds today (best: 6/10)

Cardiovascular-metabolic: No high-priority finds today (best: 7/10)

Aging/longevity: No high-priority finds today (best: 6/10)

Rare diseases: No high-priority finds today (best: 7/10)

🟢⚪ STANDARD (5-7) — Top by Topic

Hematologic Malignancies

PMID 41913678 · Novel JAK2 binding sites for MPN inhibition · 6/10 · Drug Development
PMID 41916810 · CAR-T, bispecifics, ADCs for multiple myeloma · 6/10 · Treatment Innovation
PMID 41914165 · ADC landscape in AML · 5/10 · Drug Development

Cardiovascular-Metabolic

PMID 41915388 · GLP-1 RA noncardiometabolic outcomes umbrella review (JAMA Netw Open) · 7/10 · Treatment Innovation
PMID 41917519 · Tirzepatide/lanifibranor/resmetirom for MASLD meta-analysis · 7/10 · Treatment Innovation
PMID 41914576 · GLP-1 RA effects on depression/well-being SR/MA · 6/10 · Mental Health

Early Cancer Detection

PMID 41918362 · Early-onset CRC: new risk factors? (CEBP commentary) · 5/10 · Public Health
PMID 41914308 · Cervical cancer elimination in Australia/Asia Pacific · 5/10 · Prevention

Precision Oncology

PMID 41913905 · Precision oncology in low-resource settings · 5/10 · Public Health

Novel Therapeutics

PMID 41916191 · Non-viral/mRNA-based next-gen CAR-T strategies · 6/10 · Treatment Innovation

Rare Diseases

PMID 41917266 · Rare solid tumours as indicators of hereditary cancer syndromes (EJHG) · 7/10 · Genomics

Aging/Longevity

PMID 41915085 · Cancer and aging: complex associations and therapeutic targets · 6/10 · Other

CBC/Hematology Diagnostics

PMID 41913779 · ML prediction of childhood anaemia in Ghana · 5/10 · Diagnostics

💡 UNSOLICITED FINDS

None this run. All sentinel scan results overlapped with watchlist topics.

📊 TODAY'S BREAKDOWN

By research category: Treatment Innovation 7 | Drug Development 2 | Diagnostics 3 | Early Detection 1 | Genomics/Precision Medicine 2 | Public Health 1 | Prevention 1 | Other 1
By evidence maturity: Exploratory 9 | Validated 9 | Potentially Practice-Changing 0
By watchlist topic: Hem-malig 4/10 reviewed/4 kept/8 best | CBC 1/10 reviewed/1 kept/5 best | Early detect 3/10 reviewed/3 kept/8 best | AI/ML 1/10 reviewed/1 kept/6 best | Precision onc 3/10 reviewed/3 kept/8 best | Novel Tx 2/10 reviewed/2 kept/6 best | CV-met 3/10 reviewed/3 kept/7 best | Aging 1/10 reviewed/1 kept/6 best | Rare 1/10 reviewed/1 kept/7 best
By source type: peer_reviewed 18 | preprint 0
Topics with zero 8+ articles: CBC diagnostics, AI/ML diagnostics, Novel therapeutics, CV-metabolic, Aging/longevity, Rare diseases

🔧 RUN NOTES

2-day window used (March 31 → April 2) because no run executed on April 1
No window expansion needed — sufficient relevant results across topics
No truncation triggered
No partial failures
AI/ML diagnostics topic had one article with incomplete metadata (PMID 41921663) — deferred for recovery
All prior emitted fingerprints checked; no duplicates emitted