📅 PUBMED DAILY TRIAGE — 2026-04-03 Window: 2026-04-02T09:00:00Z → 2026-04-03T09:00:00Z (CRDT) Topics scanned: 9 | Articles reviewed: ~90 | Candidates evaluated: 90+ High priority: 3 | Standard: 13 | Low/archive: 4 | Unsolicited finds: 1 Run status: SUCCESS
🔴🟠 HIGH PRIORITY (8+) — Best Finds by Topic
Hematologic Malignancies
41924907 · Treatment of TP53-mutated MDS and AML with low-intensity metronomic decitabine and venetoclax · 8/10 · Novel combination for the hardest-to-treat MDS/AML subgroup, published in Haematologica 41923577 · Targeting the Menin-KMT2A Axis in Acute Leukemia: From Epigenetic Dependency to Clinical Translation · 8/10 · Comprehensive review of 4 clinical-stage menin inhibitors (revumenib, ziftomenib, bleximinib, icovamenib) with combination strategies
Early Cancer Detection (Liquid Biopsy)
41926134 · ctDNA dynamics predict response and outcomes in early-stage NSCLC with neoadjuvant chemoimmunotherapy · 8/10 · Prospective ctDNA monitoring data showing predictive value for pathologic response in early lung cancer
Topics with no 8+ articles today: CBC/ML in hematology (best: 5/10), AI/ML diagnostics (best: 6/10), Precision oncology (best: 7/10), Immunotherapy/CAR-T (best: 7/10), Cardiovascular-metabolic (best: 7/10), Aging/longevity (best: 7/10), Rare diseases (best: 7/10)
🟢⚪ STANDARD (5-7) — Top by Topic
Hematologic Malignancies
41924919 · Targeting ceramide metabolism in AML · 6/10 · Drug Development 41926042 · Chromosome karyotyping in hematological malignancies: current status and future directions · 5/10 · Diagnostics 41926670 · Bispecific T-cell engagers in R/R B-cell NHL · 6/10 · Treatment Innovation
CBC-based Diagnostics & ML in Hematology
41923530 · Cell-MICS: Detecting immune cells with label-free two-photon autofluorescence and deep learning · 5/10 · Diagnostics
Early Cancer Detection (Liquid Biopsy)
41926475 · cfDNA fragmentomics for multi-cancer early detection · 6/10 · Early Detection 41926394 · Liquid biopsy-based ctDNA detection in post-surgical CRC surveillance · 5/10 · Early Detection
AI/ML in Clinical Diagnostics & Imaging
41924000 · AI in acute stroke imaging: current status and future directions · 6/10 · Diagnostics 41924383 · Enhanced diagnosis of diabetic retinopathy with deep learning · 5/10 · Diagnostics
Precision Oncology & Genomic Medicine
41924551 · Targeting KRAS in pancreatic cancer: potential impact on the treatment paradigm · 7/10 · Treatment Innovation 41924449 · Targeted therapy and precision medicine in advanced NSCLC · 5/10 · Genomics/PM
Immunotherapy, CAR-T, Targeted Therapy
41924604 · Perioperative ICI + chemo vs chemo alone for gastric/GEJ cancer: meta-analysis of phase III RCTs · 7/10 · Treatment Innovation 41924264 · Reprogramming TAMs in DMG/DIPG · 5/10 · Treatment Innovation
Cardiovascular-Metabolic
41923370 · Tirzepatide in metabolic diseases: efficacy beyond diabetes and obesity · 7/10 · Treatment Innovation 41923906 · Cardiometabolic risk in IgA nephropathy + telitacicept evidence · 5/10 · Treatment Innovation
Aging, Longevity & Population Health
41923646 · Memory T cell aging and rejuvenation (Immunity) · 7/10 · Aging/Immunology 41923598 · mtDNA mutation segregation and longevity · 5/10 · Basic Science
Rare Diseases
41923647 · FDA plausible mechanism framework for personalized prime editing (AJHG, co-authored by David Liu) · 7/10 · Treatment Innovation 41923552 · Epidemiology of Alport syndrome in Korea · 5/10 · Public Health
💡 UNSOLICITED FINDS
None meeting HIGH threshold. Deferred PMID 41921663 (AI in psychiatry review) recovered and classified LOW (3/10).
📊 TODAY'S BREAKDOWN
- By research category: Treatment Innovation 9 | Diagnostics 5 | Early Detection 3 | Drug Development 2 | Genomics/PM 1 | Public Health 1 | Other 2
- By evidence maturity: Exploratory 6 | Validated 12 | Potentially Practice-Changing 1
- By watchlist topic: Hem. malig. 5/5/8 | CBC/ML 1/1/5 | Liquid bx 3/3/8 | AI/ML dx 2/2/6 | Precision onc 2/2/7 | Immuno/CAR-T 3/3/7 | CV-met 2/2/7 | Aging 2/2/7 | Rare dis 2/2/7
- By source type: peer_reviewed 20 | preprint 0
- Topics with zero 8+ articles this run: CBC/ML in hematology, AI/ML diagnostics, Precision oncology, Immunotherapy/CAR-T, CV-metabolic, Aging/longevity, Rare diseases (7 of 9)
🔧 RUN NOTES
- Standard 1-day CRDT window used (no expansion needed — sufficient article volume across topics)
- Deferred PMID 41921663 from Apr 2 run recovered and classified (LOW — out of watchlist scope)
- No truncation or partial failures
- Note: 3 HIGH articles all from hematology and liquid biopsy — other topics produced strong STANDARD candidates but nothing reaching 8+ threshold today