Gambogic acid inhibits tumor growth and induces HMGB1-mediated pyroptosis in AML models in vitro and in vivo
A natural compound triggers leukemia cell death through a novel pathway while sparing normal cells, warranting further development.
This preclinical study identifies HMGB1 as a direct target of gambogic acid in AML, showing it induces pyroptosis through the AIM2 inflammasome pathway. The compound inhibited tumor growth in mouse models without significant toxicity.
What the study was
- Study design
- Preclinical (in vitro + xenograft mouse models)
- Category
- Drug Development
- Maturity
- Exploratory
- Journal
- Phytomedicine
Why it surfaced
Novel mechanism identification for gambogic acid in AML but preclinical only. Non-human study cap considered.
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