miR-193-5p, miR-1307-5p, and miR-671-5p: Potential biomarkers for chemoresistance in diffuse large B-cell lymphoma
Measuring certain molecules in tumor biopsies could help predict which patients need stronger chemotherapy upfront.
This study identifies three tissue miRNAs as potential biomarkers for predicting chemoresistance in DLBCL. While plasma levels did not correlate with prognosis, tissue-based expression showed predictive value.
What the study was
- Study design
- Exploratory biomarker study with in vitro validation
- Population
- DLBCL patients (41 retrospective biopsies + 33 prospective)
- Sample size
- 74
- Category
- Diagnostics
- Maturity
- Exploratory
- Journal
- Indian Journal of Medical Research
Why it surfaced
Exploratory biomarker discovery for DLBCL chemoresistance. Small sample, early validation stage.
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