Development and characterization of nucleosomal DNA-based reference materials for the epidermal growth factor receptor gene liquid biopsy
Stable reference materials for liquid biopsy could help labs reliably detect lung cancer mutations in blood, enabling more consistent early detection.
This study developed biologically representative nucleosomal DNA reference materials for EGFR liquid biopsy standardization at low variant allele frequencies, validated across dPCR and next-gen sequencing. The materials maintained stability for 3 years, supporting reliable clinical assay validation for EGFR mutation detection.
What the study was
- Study design
- Reference material development and validation
- Population
- Clinical laboratories performing EGFR liquid biopsy
- Category
- Diagnostics
- Maturity
- Validated
- Journal
- Analytical and Bioanalytical Chemistry
Why it surfaced
Complementary to CRM 3022/3024 above. EGFR-specific nDNA reference materials with long-term stability data. High clinical utility for cfDNA assay standardization.
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