Concept and connotation of the geroprotective and anti-aging effects of metformin: From AMPK Activation to SASP Suppression.
Metformin's multiple effects on aging processes suggest potential as a preventive therapy, though human evidence remains incomplete.
This comprehensive review examines the geroprotective and anti-aging effects of metformin, tracing its mechanisms from AMPK activation to suppression of the senescence-associated secretory phenotype (SASP). It synthesizes current evidence on metformin's potential as a geroscience intervention.
What the study was
- Study design
- Narrative review
- Category
- Prevention
- Maturity
- Exploratory
- Journal
- Molecular and cellular endocrinology
Why it surfaced
Timely review of metformin as geroprotective agent, relevant to longevity research. Review format limits novelty score.
A plain-language summary of published research — not medical advice. Talk to a clinician about your own care.