📅 PUBMED DAILY TRIAGE — 2026-04-10 Window: 2026-04-09T09:00:00Z → 2026-04-10T09:00:00Z (CRDT) Topics scanned: 10 | Articles reviewed: ~90 | Candidates evaluated: 16 High priority: 1 | Standard: 12 | Low/archive: 3 | Unsolicited finds: 0 Run status: SUCCESS
🔴🟠 HIGH PRIORITY (8+) — Best Finds by Topic
Hematologic Malignancies
41955354 · Sialylated CD43 forms a glyco-immune barrier that restrains antileukemic immunity · 8/10 · Landmark Science paper identifies novel glyco-immune checkpoint in AML — disrupting sialylated CD43 restores immune killing; new immunotherapy target class
CBC-Based Diagnostics & ML in Hematology
No high-priority finds today (topic remains sparse — 4th consecutive run)
Early Cancer Detection (Liquid Biopsy)
No high-priority finds today (best candidate scored 5/10)
AI/ML in Clinical Diagnostics
No high-priority finds today (best candidate scored 6/10)
Precision Oncology & Genomic Medicine
No high-priority finds today (best candidate scored 6/10)
Novel Therapeutics (Immunotherapy, CAR-T)
No high-priority finds today (best candidate scored 7/10)
Cardiovascular-Metabolic
No high-priority finds today (best candidate scored 6/10)
Aging, Longevity & Population Health
No high-priority finds today (best candidate scored 5/10)
Rare Diseases
No high-priority finds today (best candidate scored 6/10)
🟢⚪ STANDARD (5-7) — Top by Topic
Hematologic Malignancies
41955111 · Structure-guided design of 7-azaindole DNMT1 inhibitors active against HMA-resistant AML · 7/10 · Drug Development 41955632 · Clinical strategies for lymphoma management: Consensus Conference 2025 recommendations · 6/10 · Treatment Innovation 41957272 · Umbilical cord blood transplantation in children with Diamond-Blackfan anemia · 6/10 · Treatment Innovation
Early Cancer Detection
41957273 · Liquid biopsy + ML predicts early detection in liver disease (Nat Rev GI & Hepatol highlight) · 5/10 · Early Detection 41956145 · Electrochemical biosensing of circulating MicroRNAs in endometrial cancer · 4/10 · Diagnostics
AI/ML in Clinical Diagnostics
41957258 · Deep learning pathomics predicts gastric cancer prognosis — multicenter study (NPJ Precis Oncol) · 6/10 · Diagnostics 41957078 · FedLiverNet: federated learning for privacy-preserving liver cancer detection · 5/10 · Diagnostics
Novel Therapeutics
41957020 · Multimodal oncolytic virus + bispecific CAR-T for glioblastoma (Nat Commun, Maus/Fong labs) · 7/10 · Treatment Innovation 41956854 · Chiral nanoadjuvants reprogramming anti-tumor immunity via NLRP3/cGAS-STING · 5/10 · Treatment Innovation
Cardiovascular-Metabolic
41957114 · Real-world GLP-1 + digital coaching outcomes in multi-ethnic Asian population · 6/10 · Treatment Innovation 41957151 · Glucose disposal rate changes predict stroke risk in CKM syndrome · 5/10 · Early Detection 41957641 · Cardiac MRI body composition prognostics in diabetic HFpEF · 5/10 · Diagnostics
Aging & Population Health
41957368 · Frailty status correlates with cardiac surgery outcomes in older adults · 5/10 · Public Health
Rare Diseases
41957353 · Dual rescue of GMPPB dystroglycanopathy with GSK3β inhibition + AAV gene therapy (Nat Commun) · 6/10 · Drug Development 41957518 · UK stakeholder acceptability of SMA newborn screening — strong support · 6/10 · Public Health 41957272 · Cord blood transplant for Diamond-Blackfan anemia · 6/10 · Treatment Innovation
💡 UNSOLICITED FINDS
None today — sentinel scan did not surface novel out-of-watchlist high-signal items.
📊 TODAY'S BREAKDOWN
- By research category: Treatment Innovation (6) | Drug Development (3) | Diagnostics (4) | Early Detection (2) | Public Health (2) | Genomics/Precision Medicine (1)
- By evidence maturity: Exploratory (7) | Validated (8) | Potentially Practice-Changing (0)
- By watchlist topic: Hem Malig (4 kept, 1 HIGH) | CBC/ML (0 kept) | Liquid Biopsy (2 kept) | AI/ML Dx (2 kept) | Precision Onc (1 kept) | Immunotherapy (3 kept) | CV-Metabolic (3 kept) | Aging (2 kept) | Rare Disease (3 kept) | Sentinel (0 kept)
- By source type: peer_reviewed 16 | preprint 0
- Topics with zero 8+ articles this run: CBC/ML, Liquid Biopsy, AI/ML Dx, Precision Onc, Immunotherapy, CV-Metabolic, Aging, Rare Diseases
🔧 RUN NOTES
- No window expansion needed (16 relevant articles found within 24h window)
- CBC/ML in hematology topic has produced zero high-priority articles for 4 consecutive runs — consider broadening query or lowering threshold
- Strong single paper in Science for hematologic malignancies drives the only HIGH priority today
- No truncation applied; all topics within per-topic candidate caps