📅 PUBMED DAILY TRIAGE — 2026-04-13
Window: 2026-04-11T09:00:00Z → 2026-04-13T09:00:00Z (CRDT) Topics scanned: 10 | Articles reviewed: ~90 candidates | Kept for triage: 18 High priority: 3 | Standard: 14 | Low/archive: 1 | Unsolicited finds: 1 Run status: SUCCESS
🔴🟠 HIGH PRIORITY (8+) — Best Finds by Topic
Early Cancer Detection (Liquid Biopsy / ctDNA / cfDNA)
TR-001 / PMID 41965218 · Optimization of methylated DNA markers to rule out endometrial cancer in patients with abnormal uterine bleeding · 9/10
2-MDM panel in self-collected vaginal fluid achieves 96% sensitivity and AUC 0.97 for endometrial cancer at Mayo Clinic — could replace invasive endometrial sampling in millions of women presenting with AUB. 🔴 EARLY_CANCER_DETECTION
Hematologic Malignancies (Multiple Myeloma / CAR-T)
TR-002 / PMID 41968163 · Functionally high-risk disease is associated with poor outcomes after late-line CAR T-cell therapy for multiple myeloma · 8/10
MSKCC retrospective cohort (n=208): FHR MM pts (POD <24 months frontline) had significantly inferior OS (34 vs 55 months, p=0.025) after late-line CAR T — supports using CAR T earlier in high-risk disease. 🟠 NOVEL_TREATMENT
Rare Diseases / Novel Therapeutics (CAR-T in Autoimmune Disease)
TR-003 / PMID 41966710 · Autologous CD19/BCMA CAR-T cell therapy for myasthenia gravis: Advancing care for those with severe disease · 8/10
Commentary on Ruan et al. trial: dual-target CD19/BCMA CAR-T produced marked improvement in refractory MG with steroid discontinuation, sustained B-cell depletion, and immune reprogramming — paradigm-shifting application of CAR-T in autoimmune disease. 🟠 NOVEL_TREATMENT
🟢⚪ STANDARD (5–7) — Top by Topic
Early Cancer Detection
- TR-004 / PMID 41967049 · Presurgical ctDNA in resectable CRC liver metastases (MIRACLE cohort, n=182) · 7/10 · Diagnostics
- TR-010 / PMID 41966893 · ctDNA prognostic significance in metastatic prostate cancer — meta-analysis · 6/10 · Diagnostics
- TR-011 / PMID 41964148 · Peri-op ctDNA with custom NGS assay in HPV-neg HNSCC · 6/10 · Diagnostics
- TR-016 / PMID 41965511 · EV profiling as liquid biopsy in myelofibrosis (Mol Med) · 5/10 · Diagnostics [medium confidence]
Hematologic Malignancies
- TR-008 / PMID 41968224 · Real-world CAR-T + pembrolizumab bridging for R/R PMBCL · 6/10 · Treatment Innovation
- TR-009 / PMID 41968189 · MDS therapy strategies by decade — German MDS registry · 6/10 · Treatment Innovation
- TR-012 / PMID 41967816 · Dupilumab in AD when cutaneous lymphoma suspected — EORTC consensus · 6/10 · Diagnostics 🟢
Precision Oncology / Genomic Medicine
- TR-005 / PMID 41967638 · Genomic determinants of response to alpelisib + fulvestrant — SOLAR-1 (Ann Oncol) · 7/10 · Genomics/Precision Medicine
Novel Therapeutics
- TR-006 / PMID 41968073 · Phase 2: cabozantinib + nivolumab + ipilimumab for poorly differentiated NEC (ETCTN10315) · 7/10 · Treatment Innovation
- TR-014 / PMID 41968151 · Chemical anchoring of immunotherapy drugs in senescent tumor cells — Nat Commun [preclinical, animal] · 5/10 · Drug Development ⚪
Cardiovascular-Metabolic (GLP-1 / SGLT2)
- TR-013 / PMID 41967967 · HFpEF/obesity prevalence meeting incretin RA eligibility — PARACLETE study, Japan · 6/10 · Public Health
- TR-015 / PMID 41968100 · SGLT2 inhibitors in CKM syndrome — multidisciplinary expert perspective (Eur Heart J Cardiovasc Pharmacother) · 5/10 · Treatment Innovation 🟢
Rare Diseases
- TR-007 / PMID 41968386 · Fumarase deficiency — expanding clinical and genetic spectrum · 7/10 · Genomics/Precision Medicine 🟡
💡 UNSOLICITED FINDS
TR-017 / PMID 41967268 · Non-invasive classification of coronary perfusion pressure during CPR using smartphone-based skin video + deep learning (Comput Methods Programs Biomed) · 6/10
Out-of-watchlist AI diagnostic application: smartphone video enables non-invasive hemodynamic assessment during CPR — potentially implementable without invasive monitoring. ⚪ PROMISING_PRELIMINARY
📊 TODAY'S BREAKDOWN
By research category:
- Treatment Innovation: 7
- Diagnostics: 7
- Genomics/Precision Medicine: 2
- Drug Development: 1
- Public Health: 1
By evidence maturity:
- Validated: 8
- Exploratory: 9
- Promising but Exploratory: 1
By watchlist topic (reviewed / kept / highest score):
| Topic | Reviewed | Kept | Highest Score |
|---|---|---|---|
| Hematologic malignancies | 10 | 6 | 8 |
| Early cancer detection | 8 | 5 | 9 |
| CBC/ML in hematology | 7 | 0 | 4 |
| AI/ML in clinical diagnostics | 10 | 3 | 6 |
| Precision oncology | 9 | 2 | 7 |
| Novel therapeutics/CAR-T | 9 | 4 | 8 |
| Cardiovascular-metabolic (GLP-1/SGLT2) | 10 | 3 | 6 |
| Aging/longevity | 10 | 1 | 5 |
| Rare diseases | 6 | 3 | 8 |
| Sentinel scan | 10 | 1 | 6 |
By source type: peer_reviewed 18 | preprint 0
Topics with zero 8+ articles this run:
- CBC-based diagnostics and ML in hematology (SPARSE — 6+ consecutive runs)
- AI/ML in clinical diagnostics (highest 6/10)
- Cardiovascular-metabolic GLP-1/SGLT2 (highest 6/10)
- Aging/longevity (highest 5/10)
🔧 RUN NOTES
- Window expansion: Not triggered (≥5 relevant records found in primary 48-hour window)
- CBC/ML hematology: Zero relevant CBC+ML records found for the 6th+ consecutive run; suggest reconsidering query scope or flagging for watchlist review
- PMID 41966710 (CAR-T for MG): Classified as HIGH but is a commentary/perspective on the Ruan et al. clinical trial; the primary trial PMID should be retrieved and evaluated in a future run for complete evidence assessment
- Rare diseases query: Only 6 raw results in window — below typical threshold but all 6 reviewed; no expansion triggered
- Aging/longevity query: Very noisy (153 results); top-10 hits were predominantly non-hematology/oncology topics (dermatology, motor learning, Alzheimer's preclinical); watchlist signal remains low
- Rolling 7-day view (from state): CBC/ML hematology has yielded no high-priority articles in the past 6 days; aging/longevity last produced a STANDARD article 4-5 runs ago. Consider watchlist query refinement at next weekly review.