Long-term HIV-1 remission achieved through allogeneic haematopoietic stem cell transplant from a CCR5Δ32/Δ32 sibling donor.
Another person has achieved long-term HIV remission through bone marrow transplant, strengthening evidence that this approach can work across different patients.
A patient with HIV-1 infection achieved long-term viral remission following allogeneic bone marrow transplantation from a sibling carrying the CCR5Δ32/Δ32 mutation that renders cells resistant to HIV entry. This adds to the small but growing series of HIV cure cases (Berlin, London, Düsseldorf, City of Hope, Geneva) achieved through this mechanism.
What the study was
- Study design
- Clinical case report with prospective longitudinal follow-up
- Population
- HIV-1-positive patient with hematologic malignancy receiving allogeneic HSCT from homozygous CCR5Δ32/Δ32 sibling donor
- Sample size
- 1
- Category
- Treatment Innovation
- Maturity
- Validated
- Journal
- Nature microbiology
Why it surfaced
Adds a new confirmed case to the rare series of HIV functional cures via CCR5Δ32/Δ32 donor HSCT (Nature Microbiology); high novelty and unmet need. Single patient limits design score; matched abstract only.
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