Association of TP53 polymorphic variants rs1042522 and rs1642785 with susceptibility and prognosis of acute lymphoblastic leukemia in a Brazilian Amazon population
This study helps fill a gap in understanding childhood leukemia genetics by examining gene variants in an understudied indigenous-admixed Brazilian population.
This study examines TP53 germline variant associations with pediatric ALL susceptibility and outcomes in the Brazilian Amazon, a population with unique genetic admixture underrepresented in leukemia genomics research. Results add to the limited body of hematologic malignancy genetic data from LMIC indigenous-admixed populations.
What the study was
- Study design
- Retrospective observational (population genetics/case-control)
- Population
- Pediatric ALL patients and controls, Brazilian Amazon (HEMOAM, Manaus)
- Category
- Genomics/Precision Medicine
- Maturity
- Exploratory
- Journal
- BMC Medical Genomics
Why it surfaced
Contributes Amazon population genetics data for pediatric ALL, valuable for underrepresented ancestry. Score limited by retrospective design and lack of abstract data on sample size or effect size.
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