Ovarian tissue cryopreservation in girls and adolescents at risk of gonadotoxicity: a 15-year experience in 159 patients from a referral program
Freezing ovarian tissue helps preserve fertility in girls with cancer, with this large study showing the approach's real-world success rates.
This 15-year retrospective study of 159 girls and adolescents documents outcomes of a structured risk-based ovarian tissue cryopreservation (OTC) program for pediatric oncology patients, finding primary ovarian insufficiency in 43% of evaluable patients. The study provides a coordinated care model with clear denominator definitions for endocrine outcome tracking across hematologic and other malignancies.
What the study was
- Study design
- Retrospective observational study (n=159, single center, 15 years)
- Population
- Girls and adolescents (median age 11y) with malignant/non-malignant conditions undergoing gonadotoxic treatment; 82.3% malignant (22% leukemia/lymphoblastic lymphoma)
- Sample size
- 159
- Category
- Prevention
- Maturity
- Validated
- Journal
- Clinical & translational oncology
Why it surfaced
Largest single-center OTC experience in pediatric oncology; directly relevant to hematologic malignancy patients (HSCT, leukemia); addresses vulnerable underserved population.
A plain-language summary of published research — not medical advice. Talk to a clinician about your own care.