Metabolites in the tumor microenvironment: Key drivers of immune cell fate and function as therapeutic targets in cancer
Researchers are mapping how tumors manipulate metabolism to hide from immunity, revealing new treatment targets to restore immune control.
This review systematically examines how tumor microenvironment metabolites, particularly lactic acid and adenosine, suppress immune cell function and enable tumor escape, cataloguing current clinical trial progress in targeting these metabolic pathways as components of immunotherapy. The synthesis is relevant to understanding immunotherapy resistance mechanisms across solid tumors.
What the study was
- Study design
- Systematic narrative review
- Population
- Cancer patients (multiple tumor types)
- Category
- Treatment Innovation
- Maturity
- Exploratory
- Journal
- Biochimica et Biophysica Acta - Reviews on Cancer
Why it surfaced
BBA Reviews on Cancer is a high-quality review venue; metabolic immunotherapy targeting is a growing field; useful pipeline context but no primary data.
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