📅 PUBMED DAILY TRIAGE — 2026-04-19

Window: 2026-04-18T09:00:00Z → 2026-04-19T09:00:00Z (CRDT) Topics scanned: 10 | Articles reviewed (candidates): ~95 | Candidates with abstracts: 30 High priority: 2 | Standard: 18 | Low/archive: ~65 | Unsolicited finds: 0 Run status: SUCCESS

🔴🟠 HIGH PRIORITY (8+) — Best Finds by Topic

Aging, Longevity, and Population Health

TR-2026-04-19-001 / PMID 41999681 · Dietary total antioxidant capacity alleviates IBD-related surgery, gastrointestinal cancer, and mortality risks among middle-aged and older individuals · 8/10 · 🟢 NEAR_TERM_IMPLEMENTABLE

UK Biobank prospective cohort (n=2,487, 10.9yr median follow-up) found highest-quartile dietary antioxidant intake linked to 47% lower IBD-related surgery risk (HR 0.53), 61% lower GI cancer risk (HR 0.39), and 39% lower all-cause mortality (HR 0.61) — with gene-diet interactions identified in CAT and SLC2A14. Actionable dietary guidance for clinicians managing IBD patients.

AI/ML in Clinical Diagnostics and Imaging

TR-2026-04-19-002 / PMID 42000889 · Patch-to-slide fusion deep learning model for histological diagnosis of early pregnancy loss including hydatidiform mole · 8/10 · 🟢 NEAR_TERM_IMPLEMENTABLE

Multicenter AI model (n=1,287, NPJ Digital Medicine) achieved AUROC 0.959 in development and 0.930 in independent testing for classifying complete/partial mole vs hydropic abortion; AI assistance significantly improved pathologist accuracy (p<0.05). Addresses a real-world unmet need where current gold standards (molecular profiling) are too costly for routine use.

🟢⚪ STANDARD (5–7) — Top by Topic

Hematologic Malignancies (AML, MDS, CLL, MPN, Lymphoma)

• TR-019-005 / 42000061 · Behavioral intervention (ReSET) to improve symptoms post-HCT, pilot RCT n=39 · 7/10 · Pilot RCT; feasibility confirmed, preliminary efficacy for sleep/depression
• TR-019-019 / 42000415 · ENKTL molecular biology and EBV virologic advances over 40 years · 5/10 · Review; >80% 5-yr OS in localized disease with modern chemoradiotherapy; ICI combinations emerging

Early Cancer Detection / Liquid Biopsy

• TR-019-007 / 42001180 · Liquid biopsy: CTC burden + immune status + protein profiles in metastatic breast cancer (ALCINA 2 prospective) · 6/10 · Multi-analyte CTC liquid biopsy linking immune and proteomic landscape to outcomes
• TR-019-008 / 42001157 · EV protein biomarkers for HCC: mechanisms, methods, and translation (review) · 6/10 · 🔴 EARLY_CANCER_DETECTION; biochip-based EV proteomics advancing toward clinical translation

AI/ML in Clinical Diagnostics and Imaging

• TR-019-009 / 42001128 · LGSOC survival risk prediction model + deep learning, multicenter n=155 · 6/10 · DL model C-index 0.922 for OS vs FIGO 0.679; rare ovarian cancer subtype with unmet need
• TR-019-013 / 42001158 · MRI-based clinical-radiomics model for HCC interventional + systemic therapy (multicenter) · 6/10 · Radiomics for HCC treatment response prediction; multicenter design
• TR-019-014 / 41998835 · CINV prediction algorithm using glutathione recycling + individual factors, n=202 · 6/10 · Blood-based algorithm predicts delayed chemo nausea severity; first CBC/ML qualifying article in 13 days

Precision Oncology and Genomic Medicine

• TR-019-003 / 41999752 · Pan-cancer spatial transcriptomics, n=373 samples, 12 cancer types (Cell Reports Med) · 7/10 · Niche_4 (macrophage+tumor) = poor prognosis/ICI resistance; Niche_11 (macrophage+immune) = better survival; spatial niches predict immunotherapy response
• TR-019-006 / 41999684 · PIK3CA testing consensus for advanced HR+/HER2- breast cancer (Italy, 23/29 statements 100% agreement) · 7/10 · 🟢 NEAR_TERM_IMPLEMENTABLE; standardized testing for ~40% of HR+/HER2- BC patients eligible for alpelisib/inavolisib
• TR-019-012 / 42001161 · Serial pan-immune-inflammation value predicts cytoreduction at IDS in advanced ovarian cancer (retrospective) · 6/10 · Blood-based inflammatory index as pre-surgical prediction tool; abstract not fully retrieved
• TR-019-017 / 42001193 · B7 family (CD276/VTCN1/HHLA2) subgroups in gallbladder cancer; HHLA2-EMT via RAC1/PAK1 axis; ML survival model n=188 · 5/10 · Mechanistic + ML novelty in rare cancer

Novel Therapeutics

• TR-019-020 / 41999844 · TME metabolites (lactate, adenosine) as immunotherapy targets: systematic review of clinical progress · 5/10 · Context-useful review; no new primary data
• TR-019-018 / 41999539 · HER2+ urothelial carcinoma: Treg enrichment + low classical checkpoints; RC48 + PD-1 biological rationale (n=29) · 5/10 · Explores mechanistic basis for RC48 + ICI combination; small n

Cardiovascular-Metabolic / GLP-1 / SGLT2

• TR-019-004 / 41999054 · GLP-1 RAs on muscle mass/strength/quality in MASLD: systematic review n=810 (Liver Int) · 7/10 · Muscle preservation reassured; 12 studies; addresses key safety concern for widely prescribed drug class
• TR-019-011 / 42001134 · RCT nurse-led self-management for diabetic retinopathy post-vitrectomy, n=120 (BMC Ophthalmol) · 6/10 · Significantly improved self-management and distress at 6 months; registered RCT
• TR-019-015 / 42001194 · International consensus on adolescent metabolic health: prevention of obesity and T2D · 6/10 · 🟡 UNDERSERVED_POPULATION; multinational including LMIC; gap in pediatric/adolescent metabolic guidelines

Aging, Longevity, and Population Health

• TR-019-016 / 42001125 · Structural roots of multimorbidity in Southern Spain (mixed-methods, n=1,592 + 18 interviews) · 5/10 · 5 socially stratified multimorbidity patterns; cardiometabolic clustering in deprived populations

Rare Diseases with High Unmet Need

• TR-019-010 / 42000952 · Dent disease in Korean children, multicenter n=48 (9 hospitals) (Pediatr Nephrol) · 6/10 · 🟡 UNDERSERVED_POPULATION; 39.5% progress to kidney dysfunction by early adulthood; underdiagnosis due to phenotypic variability highlighted

💡 UNSOLICITED FINDS

None qualifying this run. Sentinel scan (298 candidates, broad signal query) produced no articles not already captured by watchlist searches.

📊 TODAY'S BREAKDOWN

By Research Category

• Diagnostics: 8 articles
• Prevention: 3
• Treatment Innovation: 5
• Genomics/Precision Medicine: 2
• Public Health: 1
• Early Detection: 1

By Evidence Maturity

• Validated: 7 (41999681, 42000889, 41999054, 42001134, 41999684, 42001194, 42000415)
• Exploratory: 12
• Potentially Practice-Changing: 1 (41999684 — PIK3CA consensus)

By Watchlist Topic (reviewed / kept / highest score)

By Source Type

• Peer reviewed: 20 | Preprints: 0

Topics with Zero 8+ Articles This Run

• Hematologic malignancies, Early cancer detection/liquid biopsy, Precision oncology, Novel therapeutics, Cardiovascular-metabolic, Rare diseases, CBC/ML hematology, Sentinel scan

🔧 RUN NOTES

• Window: 24hr incremental CRDT window from previous checkpoint; no expansion triggered (>5 articles found)
• Deferred PMIDs from 2026-04-18 PARTIAL_SUCCESS: 45 PMIDs queued from prior run (41991xxx–41998xxx range) were not re-processed this run as they fall outside today's CRDT window. Recommend explicit catch-up search or manual review.
• CBC/ML hematology: Topic produced 1 qualifying STANDARD article (PMID 41998835, CINV prediction) after 13 consecutive no-qualifying-article days. Note: algorithm uses RBC glutathione recycling capacity rather than traditional CBC morphology parameters.
• Abstract retrieval gaps: PMIDs 42001180, 42001161, 42001158 returned no abstract text via efetch (title/metadata only); classification_confidence downgraded to medium for these three records.
• No truncation events: All topic caps (10 candidates) were applied without silent dropping.
• Alerts sent: 2 Telegram alerts issued (PMID 41999681, PMID 42000889). Alert dedup keys: 2026-04-19-TR-2026-04-19-001 and 2026-04-19-TR-2026-04-19-002.
• Rolling 7-day view (from state history): Novel therapeutics has scored max 5/10 for 7 consecutive days; Hematologic malignancies produced max 7/10 today (ReSET post-HCT RCT) but no 8+ articles; CBC/ML hematology broke a 13-day drought today.