Integrating Recent Evidence and Expert Perspectives Into the Management of Multiple Myeloma: Consensus Recommendations From the 2025 Bridging the Gaps Conference
Multiple myeloma experts agreed on practical treatment steps—using four-drug combinations and checking for remaining cancer cells—providing clearer guidance for doctors navigating this complex disease.
Sixteen US multiple myeloma experts convened using a modified Delphi approach to develop 11 consensus recommendations spanning smoldering MM through relapsed/refractory disease, with key themes of quadruplet induction, MRD-guided maintenance, and early CAR-T referral. These expert-derived recommendations provide practical guidance for clinicians while identifying ongoing areas of uncertainty in MM management.
What the study was
- Study design
- Expert consensus (modified Delphi, 16 US MM experts, 51 questions)
- Population
- Multiple myeloma patients across disease stages
- Category
- Treatment Innovation
- Maturity
- Potentially Practice-Changing
- Journal
- American Journal of Hematology
Why it surfaced
Expert consensus in high-impact hematology journal addresses practical clinical uncertainty in MM management; near-term implementable guidance for community oncologists on quadruplet therapy and CAR-T referral timing.
A plain-language summary of published research — not medical advice. Talk to a clinician about your own care.