Multi ancestry genome wide association meta analysis of urinary aMT6s levels
The first large genetic study of melatonin metabolism suggests multiple genes influence sleep and metabolic traits across populations.
The first multi-ancestry GWAS of urinary melatonin metabolite aMT6s (n=11,744) found no genome-wide significant hits, suggesting a polygenic and population-dependent genetic architecture. PRS-level associations with T2D and sleep duration provide a foundation for future melatonin-related metabolic research but require cautious interpretation due to limited power.
What the study was
- Study design
- Multi-ancestry GWAS meta-analysis
- Population
- Multi-ancestry participants from 5 cohorts (East Asian, European, multiethnic)
- Sample size
- 11744
- Category
- Genomics/Precision Medicine
- Maturity
- Exploratory
- Journal
- Scientific Reports
Why it surfaced
First multi-ancestry GWAS of aMT6s; n=11,744; establishes genomic framework for melatonin-related cancer and metabolic research.
A plain-language summary of published research — not medical advice. Talk to a clinician about your own care.