Endovascular profiles linked to neutrophil activation in children and young adults with long COVID
Children with long COVID show blood clots and immune markers linked to heart complications, offering potential diagnostic targets.
Children and young adults with long COVID show elevated microclots, NET-associated cfDNA, and endothelial injury markers, with in vitro evidence implicating Spike-mediated NETosis as a driver of endovascular pathology. This understudied pediatric population data identifies microclots + neutrophil activation as potential diagnostic biomarkers for long COVID cardiovascular complications.
What the study was
- Study design
- Case-control study
- Population
- Children and young adults ≤25 years; 61 long COVID, 23 healthy controls; US and Canada
- Sample size
- 84
- Category
- Diagnostics
- Maturity
- Exploratory
- Journal
- Pediatric Research
Why it surfaced
Pediatric long COVID endovascular mechanism study; cfDNA as NET biomarker is watchlist-adjacent; addresses understudied pediatric population.
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