ChREBP-mediated regulation of lipid metabolism in liver and brown adipose tissue of long-lived mice
Five long-lived mouse models share a pattern of reduced liver fat production and increased brown fat—a potential aging intervention target.
Five genetically distinct slow-aging mouse models share a conserved pattern of reduced hepatic de novo lipogenesis and enhanced brown adipose tissue lipogenesis, mediated by ChREBP. This finding proposes tissue-specific ChREBP-regulated DNL as a potential mechanistic link in longevity biology with implications for metabolic aging interventions.
What the study was
- Study design
- Preclinical animal study
- Population
- Five long-lived mouse models (Ames, Snell, GHR-KO, Pappa-KO, PTENOE)
- Category
- Other
- Maturity
- Exploratory
- Journal
- GeroScience
Why it surfaced
Five-model conserved longevity metabolic signature; preclinical but well-controlled across multiple genetic models; scored cap at 5 (non-human only).
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