Danshensu Ethyl Ester Induces Ferroptosis Through Targeted Inhibition of SLC7A11 Transport Function in NSCLC.
A plant-derived compound triggered tumor cell death in lung cancer models as effectively as standard chemotherapy, warranting further exploration toward human trials.
This preclinical study demonstrates that DEE, a derivative of the traditional herb Danshensu, induces ferroptosis in NSCLC through targeted inhibition of SLC7A11 (xCT) cysteine transporter function independently of p53 status. DEE suppressed tumor growth in nude mouse xenografts with antitumor efficacy comparable to paclitaxel, positioning it as a potential novel therapeutic agent for NSCLC — though human data are absent.
What the study was
- Study design
- Preclinical in vitro + in vivo xenograft study
- Population
- NSCLC cell lines (A549, H1299) + nude mouse xenograft model
- Category
- Drug Development
- Maturity
- Exploratory
- Journal
- Thoracic Cancer
Why it surfaced
DEE-SLC7A11 ferroptosis mechanism is novel and p53-independence addresses a common resistance point; triage score capped at 5 per non-human study rule.
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