Association Between Allostatic Load and Incident Colorectal Cancer—A Prospective Study in a Multiethnic Asian Population
High cumulative stress markers predict colorectal cancer risk in Asian populations, potentially enabling early screening of vulnerable individuals.
This large prospective study (n=30,443; 162 CRC cases; median follow-up 7.2 years) in a multiethnic Asian population demonstrates that high allostatic load is independently associated with 53% elevated colorectal cancer risk. This finding extends prior Western evidence to Asian populations and suggests allostatic load could serve as a scalable population-level cancer risk stratification tool.
What the study was
- Study design
- Prospective cohort study (registry-linked)
- Population
- Chinese, Malay, and Indian adults ≥18y in Singapore Multi-Ethnic Cohort
- Sample size
- 30443
- Category
- Prevention
- Maturity
- Validated
- Journal
- Cancer Medicine
Why it surfaced
Large Asian cohort (n=30k) linking physiological stress burden to CRC incidence; extends allostatic load research to underrepresented multiethnic Asian populations with policy relevance for cancer prevention strategies.
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