Self-Assembled DNA Nanoladder-Based Electrochemical Biosensor for Rapid and Sensitive Detection of Bladder Tumor-Related miRNA in Urine
A laboratory urine test detects bladder cancer markers at ultra-low levels, though human validation studies remain pending.
A DNA nanoladder-based electrochemical biosensor achieves attomolar-level detection of urinary miR-126 for bladder cancer screening with impressive analytical performance and promising accuracy in a very small pilot cohort (n=25). This represents an early-stage proof-of-concept for non-invasive urinary liquid biopsy.
What the study was
- Study design
- Biosensor development + small clinical validation cohort
- Population
- 15 bladder cancer patients + 10 negative controls
- Sample size
- 25
- Category
- Early Detection
- Maturity
- Exploratory
- Journal
- Analytical Chemistry
Why it surfaced
Novel biosensor technology with impressive analytical performance; clinical cohort n=25 too small for reliable diagnostic metric estimates; early-stage proof-of-concept.
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