Phosphatidylinositol transfer protein-1 integrates insulin/IGF-1 and TOR signaling to negatively regulate lifespan and healthspan in Caenorhabditis elegans
Suppressing a single gene extended healthy lifespan in worms by activating a longevity pathway worth studying in mammals.
This C. elegans study identifies pitp-1 as a novel aging regulator that integrates insulin/IGF-1 and TOR signaling; its suppression extends healthspan and lifespan through neuronal TOR inhibition, providing a new longevity pathway target. Results are preclinical and require mammalian validation.
What the study was
- Study design
- C. elegans genetic/mechanistic study
- Category
- Prevention
- Maturity
- Exploratory
- Journal
- Journal of Biomedical Science
Why it surfaced
Invertebrate longevity mechanistic study; scored 4 per non-human cap; identifies novel pitp-1 aging pathway target.
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