Distribution characteristics and influencing factors of active cytomegalovirus infection in patients with hematological malignancies complicated with sepsis
Simple low white-blood-cell counts help identify life-threatening viral infections early in blood-cancer patients, enabling faster intervention.
This retrospective study of 119 hematological malignancy patients with sepsis found a high early active CMV infection rate (34.45%), with decreased WBC count serving as the most useful early screening indicator (AUC=0.746), a finding that is immediately actionable as WBC is universally available. The significant association with 28-day mortality emphasizes the need for early CMV monitoring in this high-risk immunocompromised population.
What the study was
- Study design
- Single-center retrospective cohort study
- Population
- Patients with hematological malignancies complicated by sepsis (Ningbo, China, June 2022-June 2025)
- Sample size
- 119
- Category
- Diagnostics
- Maturity
- Exploratory
- Journal
- European Journal of Clinical Microbiology & Infectious Diseases
Why it surfaced
WBC as early CMV screening biomarker is immediately implementable; high incidence (34.45%) in hematologic malignancy + sepsis is clinically important; single-center retrospective limits confidence.
A plain-language summary of published research — not medical advice. Talk to a clinician about your own care.