Cytokines and cancer-associated fibroblasts
A review identifies how immune signals fuel cancer-supporting cells, pinpointing targets but highlighting why lab findings haven't yet translated to patients.
This J Hematol Oncol review systematically maps cytokine-CAF interactions across major cytokine families and evaluates therapeutic implications for precision oncology. Key challenges include cytokine pleiotropy, feedback compensation, and preclinical model limitations that currently impede clinical translation of CAF-targeting approaches.
What the study was
- Study design
- Systematic narrative review
- Population
- Pan-cancer, tumor microenvironment focus
- Category
- Treatment Innovation
- Maturity
- Exploratory
- Journal
- Journal of Hematology & Oncology
Why it surfaced
High-quality J Hematol Oncol review of CAF-cytokine axis with therapeutic framing; useful landscape review for TME immunotherapy pipeline but no new data.
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