Multiple inflammatory cytokines correlate with the vestibular and oculomotor dysfunction in Fabry disease: a prospective, longitudinal study
Specific inflammatory markers in rare Fabry disease correlate with eye and balance problems, suggesting inflammation drives these symptoms.
This prospective longitudinal study of 40 Fabry disease patients demonstrates that specific inflammatory cytokines (particularly TNF-β, IL-2, IL-17A) correlate with vestibular and oculomotor dysfunction, suggesting inflammation-mediated neural damage as a key pathomechanism in this rare lysosomal storage disease. TNF-β correlates linearly with saccade latency and accuracy measures, providing potential inflammatory biomarkers for monitoring disease progression and treatment response.
What the study was
- Study design
- Prospective observational longitudinal study
- Population
- Fabry disease patients (n=40), Peking University First Hospital
- Sample size
- 40
- Category
- Diagnostics
- Maturity
- Exploratory
- Journal
- Frontiers in Immunology
Why it surfaced
Prospective study in rare disease with novel inflammatory cytokine profiling; provides biomarker hypothesis but small N (40) and single-center limit strength.
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