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‹ Tue · 5 May 2026
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Psychological distress and quality of life in patients with indolent non-Hodgkin lymphoma

Nearly one-third of patients with slow-growing lymphoma experience significant psychological distress, highlighting the need for mental health screening during observation.

Nearly one-third of indolent NHL patients (30.7%) meet the HADS threshold for psychological distress, which is the strongest independent predictor of reduced HRQoL (β=−0.605), with watchful waiting patients and women at highest risk. These findings underscore the need for routine psychological screening integrated into iNHL follow-up, particularly during observation periods.

What the study was

Study design
Cross-sectional observational study with validated PRO instruments
Population
Adults with histologically confirmed indolent B-cell or T-cell NHL, Netherlands
Sample size
352
Category
Public Health
Maturity
Validated
Journal
Supportive Care in Cancer

Why it surfaced

Well-powered cross-sectional study with validated instruments quantifying psychological burden in iNHL; adds to supportive care evidence base.

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