Acute coronary syndrome is associated with acute kidney injury on admission but not during hospital stay
Acute kidney injury accompanying heart attacks reflects pre-existing cardiovascular-renal vulnerability rather than treatment harm, enabling better risk stratification on admission.
In 21,328 patients admitted for chest pain with 6,685 confirmed ACS cases, ACS was strongly associated with AKI on admission (OR 2.52) but not de novo hospital-acquired AKI, suggesting a pre-existing shared cardiovascular-renal vulnerability rather than procedural/treatment harm. The synergistic mortality effect of AKI+ACS combination identifies a high-risk phenotype requiring early renal monitoring on admission.
What the study was
- Study design
- Retrospective cohort study
- Population
- Patients admitted for chest pain to a regional Hong Kong hospital (2021); 6,685 confirmed ACS
- Sample size
- 21328
- Category
- Public Health
- Maturity
- Exploratory
- Journal
- Renal Failure
Why it surfaced
Large retrospective cohort (N=21,328) with clinically relevant finding about ACS-AKI co-presentation; limited novelty but good evidence quality; sentinel find
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