Cellular senescence: from pathogenic mechanisms to precision anti-aging interventions
Rather than eliminating all aging cells, selective removal of only harmful senescent cells while keeping beneficial ones may be safer and more effective.
This West China Hospital review proposes a new senescence management paradigm centered on preventing detrimental senescence at its source, then using single-cell omics and lineage tracing to identify and selectively clear 'maladaptive' senescent cells while preserving physiologically beneficial ones. The approach challenges the blanket senostatic/senolytic paradigm and advocates for functional subtype classification before intervention.
What the study was
- Study design
- Narrative review
- Category
- Treatment Innovation
- Maturity
- Exploratory
- Journal
- Aging (Albany NY)
Why it surfaced
Aging-focused review with novel 'precision anti-aging' paradigm using single-cell omics; directly on aging/longevity watchlist.
A plain-language summary of published research — not medical advice. Talk to a clinician about your own care.