📅 PUBMED DAILY TRIAGE — 2026-05-10
Window: 2026-05-09T09:00Z → 2026-05-10T09:00Z (CRDT) Topics scanned: 10 | Candidates reviewed: 30 | Articles kept: 17 High priority: 1 | Standard: 16 | Low/archive (count-only): 13 | Unsolicited finds: 2 Run status: SUCCESS
🔴🟠 HIGH PRIORITY (8+) — Best Finds by Topic
Novel Therapeutics: Immunotherapy / CAR-T / Targeted Therapy
TR-2026-05-10-001 / PMID 42104840 · Rationale and Design of CARDIO-TTRansform, a Phase 3 Trial of Eplontersen in Transthyretin Amyloid Cardiomyopathy · Score: 7/10 🟠 NOVEL_TREATMENT
Why it matters: Largest ATTR cardiomyopathy RCT ever (n=1,432 fully enrolled). Eplontersen is a novel N-GalNAc antisense oligonucleotide that silences hepatic TTR mRNA production — a mechanistically distinct approach from TTR stabilizers. Phase 3, 140-week follow-up, CV mortality + recurrent CV events primary endpoint. No results yet (design paper), but publication of results will be practice-defining for ATTR-CM management.
Hematologic Malignancies: No high-priority finds today (best candidate: PMID 42104607 scored 6/10)
CBC-based diagnostics and ML in hematology: No high-priority finds today (topic empty — 18th consecutive empty window)
Early cancer detection (liquid biopsy, ctDNA, cfDNA): No high-priority finds today (topic empty this run)
AI/ML in clinical diagnostics and imaging: No high-priority finds today (best candidate: 5/10)
Precision oncology and genomic medicine: No high-priority finds today (best candidate: 3/10)
Cardiovascular-metabolic: No high-priority finds today (best candidates: 7/10 — just below threshold)
Aging, longevity, and population health: No high-priority finds today (best candidate: 5/10)
Rare diseases with high unmet need: No high-priority finds today (best candidate: 7/10 — just below threshold)
🟢⚪ STANDARD (5–7) — Top by Topic
Hematologic Malignancies (AML, MDS, CLL, MPN, Lymphoma)
- TR-2026-05-10-005 / PMID 42104607 · CADM1 and TIAM1 Expressions in Mycosis Fungoides: Diagnostic Significance · 6/10 · Diagnostics
- TR-2026-05-10-009 / PMID 42104717 · Blinatumomab Utilization in Pediatric B-ALL: Experience From the Mountain West · 5/10 · Treatment Innovation
AI/ML in Clinical Diagnostics and Imaging
- TR-2026-05-10-011 / PMID 42104560 · Multimodal Nomogram for Prenatal HLHS Risk Assessment Using Self-Supervised Learning · 5/10 · Diagnostics (AUC 0.991)
- TR-2026-05-10-012 / PMID 42104545 · Transformer-Based DL Model for Predicting Recurrence in High-Grade Glioma · 5/10 · Diagnostics (AUC 0.903 train / 0.747 test)
- TR-2026-05-10-013 / PMID 42104541 · 3D Deep Learning for Automated NT Plane Detection in First-Trimester Ultrasound · 5/10 · Diagnostics (91.6% success, prospective)
- TR-2026-05-10-014 / PMID 42104715 · Early Diagnosis of Alzheimer's Disease Through Handwriting Analysis and Deep Learning: A Review · 4/10 · Diagnostics
Cardiovascular-Metabolic: GLP-1, SGLT2, Cardiometabolic Risk
- TR-2026-05-10-003 / PMID 42104850 · Integrated Cardiometabolic Genetic Testing in a Predominantly Hispanic Population · 7/10 · Genomics/Precision Medicine 🟡 UNDERSERVED_POPULATION
- TR-2026-05-10-004 / PMID 42104798 · Empagliflozin RCT in Schizophrenia Patients on Antipsychotics · 7/10 · Treatment Innovation 🟡 UNDERSERVED_POPULATION
- TR-2026-05-10-006 / PMID 42104592 · Cardiometabolic Risk Markers and Arterial Stiffness Progression in Prediabetes (n=5,771) · 6/10 · Prevention
- TR-2026-05-10-008 / PMID 42104724 · Systematic Review: Disease-Modifying Therapies in Parkinsonian Disorders (GLP-1 RAs covered) · 5/10 · Drug Development
Aging, Longevity, and Population Health
- TR-2026-05-10-010 / PMID 42104655 · Circulating Sphingomyelins Correlate With T-Tau in Preclinical Alzheimer's Disease · 5/10 · Early Detection
Rare Diseases with High Unmet Need
- TR-2026-05-10-002 / PMID 42104851 · Nationwide NBS for Mucopolysaccharidoses in Taiwan (n=838,585, 10-year outcomes) · 7/10 · Early Detection 🟢 NEAR_TERM_IMPLEMENTABLE
- TR-2026-05-10-015 / PMID 42104555 · SMA Types 2 & 3 Clinical Characterization in Brazil (n=155, 9 national centers) · 4/10 · Public Health
- TR-2026-05-10-016 / PMID 42104577 · First Successful HSCT in POLD1 Deficiency — 2-Year Experience · 4/10 · Treatment Innovation
💡 UNSOLICITED FINDS
TR-2026-05-10-007 / PMID 42104753 · SWHSI-2: NPWT vs Usual Care for Surgical Wounds Healing by Secondary Intention — Pragmatic RCT (n=686, NHS) · 6/10 · 🟢 NEAR_TERM_IMPLEMENTABLE
- Large NIHR-funded pragmatic RCT showing NPWT is NOT clinically or cost-effective for surgical wounds in predominantly diabetic patients (median healing 187 vs 195 days, HR 1.08, p=0.47; NPWT costs higher). Practice-stopping negative result with real-world NHS savings implications.
TR-2026-05-10-017 / PMID 42104804 · VR-CBTp vs CBTp for Paranoid Ideation: Session-Level RCT Secondary Analysis (n=98) · 5/10 · Mental Health
- Faster clinician-rated paranoia improvement in VR-CBTp from session 3 onward; fewer sessions required for treatment completion. Interesting efficiency signal in mental health treatment technology.
📊 TODAY'S BREAKDOWN
By research category:
- Diagnostics: 6
- Treatment Innovation: 5
- Early Detection: 2
- Prevention: 2
- Drug Development: 1
- Public Health: 2
- Genomics/Precision Medicine: 1
By evidence maturity:
- Exploratory: 9
- Validated: 7
- Potentially Practice-Changing: 1
By watchlist topic (reviewed / kept / highest score):
| Topic | Reviewed | Kept | Highest Score |
|---|---|---|---|
| Hematologic malignancies | 4 | 2 | 6 |
| CBC/ML hematology | 0 | 0 | 0 |
| Early cancer detection | 0 | 0 | 0 |
| AI/ML diagnostics | 6 | 4 | 5 |
| Precision oncology | 1 | 0 | 3 |
| Novel therapeutics | 4 | 1 (HIGH) | 7 |
| Cardiovascular-metabolic | 4 | 4 | 7 |
| Aging/longevity | 2 | 1 | 5 |
| Rare diseases | 2 | 3 | 7 |
| Sentinel | 10 | 2 (unsolicited) | 6 |
By source type: Peer-reviewed: 17 | Preprint: 0
Topics with zero 8+ articles: ALL topics (no article scored ≥8 on raw score; only NOVEL_TREATMENT flag elevated PMID 42104840 to HIGH)
🔧 RUN NOTES
- CBC/ML hematology: 18th consecutive empty window. Zero indexed articles in CRDT range. Consider widening search to 48h or broadening query on next empty occurrence.
- Early cancer detection: Zero results today. This topic produced back-to-back 9/10 articles yesterday (PMID 42104826 cfDNA, PMID 42102976 HelioLiver). Likely a daily volume artifact — topic active, just quiet today.
- CARDIO-TTRansform (PMID 42104840): Flagged HIGH via NOVEL_TREATMENT rule. This is a design/rationale paper — no efficacy data. Alert sent to Telegram. Follow for results publication (trial enrolled 2024–2025 per NCT04136171).
- Cardiovascular-metabolic had 2 articles at 7/10 (PMID 42104850 and 42104798) — both near-threshold but below 8. Strong topic today overall.
- Rare diseases also had 7/10 article (PMID 42104851, Taiwan MPS NBS) — near-threshold.
- 13 LOW articles discarded (count-only): 42104824, 42104634, 42104780, 42104787, 42104772, 42104771, 42104767, 42104705, 42104680, 42104632, 42104610, 42104552, 42104700. Mix of off-watchlist RCTs, case reports, in-vitro studies, and low-relevance bibliometrics.
- No window expansion triggered (17 relevant records > 5 threshold).
- Rolling pattern note: CBC/ML hematology has produced zero HIGH articles for 18 consecutive windows. Watchlist topic is valid (recent prior HIGHs on AI-CBC integration) but this daily CRDT window approach may systematically miss articles indexed with delay. Consider weekly supplementary search on this topic.