Single cell mechanodeformation signatures as early biomarkers for hematological malignancies
Cell shape changes show promise as a label-free early diagnostic signal for blood cancers, though large-scale validation is still needed.
This critical review synthesizes current evidence for mechanodeformation signatures — biomechanical profiling of individual blood cells — as a label-free early diagnostic tool for leukemias, multiple myeloma, and lymphomas. While biological plausibility is supported and intra-study discrimination shown, large-scale multi-site validation and standardization are still needed before routine clinical implementation.
What the study was
- Study design
- Critical review of mechanobiological biomarker approaches
- Population
- Patients with leukemia, multiple myeloma, and lymphoma (review of clinical readiness studies)
- Category
- Diagnostics
- Maturity
- Exploratory
- Journal
- Critical Reviews in Clinical Laboratory Sciences
Why it surfaced
Relevant review for CBC/ML hematology topic, which has been sparse for 22 consecutive runs. Covers label-free single-cell biomechanical approach as a novel biomarker modality. Design quality scored 0 (review article).
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