📅 PUBMED DAILY TRIAGE — 2026-05-15
Window: 2026-05-14T09:00:00Z → 2026-05-15T09:00:00Z (CRDT)
Topics scanned: 10 | Articles reviewed: ~89 unique PMIDs | Candidates evaluated: ~89
High priority: 2 | Standard: 14 | Low/archive: 20 | Unsolicited finds: 0
Run status: SUCCESS
🔴🟠 HIGH PRIORITY (8+ or NOVEL_TREATMENT/EARLY_CANCER_DETECTION flag) — Best Finds by Topic
CBC-Based Diagnostics & Machine Learning in Hematology + Early Cancer Detection
TR-2026-05-15-001 / PMID 42135686 · Full BLOOD count TRends for colorectal cAnCer deteCtion (BLOODTRACC): external validation of dynamic clinical prediction models for early detection of colorectal cancer in primary care. · 9/10 · 🔴 EARLY_CANCER_DETECTION
→ External validation of CBC-trend prediction models for CRC in primary care — the strongest find of the run. Routine blood count data powering validated early detection tools at population scale. Virdee PS et al., BMC Cancer, 2026 May 14. DOI: 10.1186/s12885-026-16179-9
Novel Therapeutics: Immunotherapy
TR-2026-05-15-002 / PMID 42135568 · Betrixaban activates cGAS-STING to promote antitumor immunity without pathological inflammation. · 5/10 (preclinical cap) / HIGH by NOVEL_TREATMENT flag · 🟠 NOVEL_TREATMENT
→ FDA-approved anticoagulant repurposed as dual immunomodulator: noncanonical cGAS-STING activation boosts CD8+ T cell infiltration and synergizes with checkpoint blockade while suppressing cytokine storm — solves the antitumor/anti-inflammatory balance problem in ICI therapy. Zhao Y et al., EMBO Molecular Medicine, 2026 May 14. DOI: 10.1038/s44321-026-00429-1
🟢⚪ STANDARD (5–7) — Top by Topic
Hematologic Malignancies
- TR-2026-05-15-014 / PMID 42135593 · Early-Life Exposures and Risk of Multiple Myeloma: A Population-Based Case-Control Study in Australia. · 5/10 · Prevention
(No high-priority finds today for this topic; best candidate scored 5/10)
Early Cancer Detection / Liquid Biopsy
- TR-2026-05-15-003 / PMID 42135124 · Diagnostic Accuracy of Liquid-Based Biomarkers for Detecting and Risk Stratifying Upper Tract Urothelial Cancers: EAU Guidelines UTUC Panel systematic review. · 7/10 · Diagnostics — RNA panels (sen 86-92%/spec 87-93%), DNA methylation panels (sen 91%/spec 100%), ctDNA >6.5 copy burden (sen 71%/spec 94%) across 32 studies; evidence certainty LOW
- TR-2026-05-15-005 / PMID 42135055 · HCC attributable to HBV, HCV and other risk factors: updated global/regional/national systematic review and meta-analysis. · 7/10 · Public Health — Gut 2026; quantified preventable HCC fractions at global scale 🟢
AI/ML in Clinical Diagnostics
- TR-2026-05-15-007 / PMID 42134981 · ML models for ischaemic stroke reperfusion outcome prediction: systematic review and meta-analysis. · 7/10 · Diagnostics 🟢
- TR-2026-05-15-010 / PMID 42135669 · Deep learning CT radiomics for ALK rearrangement prediction in lung adenocarcinoma. · 6/10 · Diagnostics ⚪
- TR-2026-05-15-011 / PMID 42135672 · CT radiomics nomogram for PDAC differentiation grading: two-center retrospective. · 6/10 · Diagnostics ⚪
- TR-2026-05-15-013 / PMID 42135678 · Predictive algorithm vs. cardiologist for 90-day readmission in decompensated CHF. · 6/10 · Diagnostics 🟢
- TR-2026-05-15-015 / PMID 42135000 · What's new in digital and computational pathology 2026. · 5/10 · Review ⬜
Novel Therapeutics / Immunotherapy
- TR-2026-05-15-006 / PMID 42135603 · ICI + CRT vs. consolidative ICI alone in unresectable cancers: systematic review and meta-analysis. · 7/10 · Treatment Innovation 🟠
- TR-2026-05-15-016 / PMID 42135764 · Bidirectional NAD/NAMPT ↔ IFN-γ/PD-L1 regulation via BRD4/IRF1 in metastatic melanoma. · 4/10 · Drug Development ⚪
Precision Oncology
- (Shared with AI/ML and Immunotherapy above: 42135669, 42135672, 42135603)
Cardiovascular-Metabolic (GLP-1/SGLT2)
- TR-2026-05-15-009 / PMID 42135769 · Exercise RCT: 12-week combined training on adropin + arterial stiffness in postmenopausal T2D women. · 7/10 · Prevention 🟢
- TR-2026-05-15-012 / PMID 42135627 · SGLT2 inhibitors on nutritional and immunologic status in chronic heart failure. · 6/10 · Treatment Innovation 🟢
- TR-2026-05-15-013 / PMID 42135678 · (shared above)
Aging, Longevity, and Population Health
- TR-2026-05-15-004 / PMID 42135576 · Reduced ULK1 links impaired autophagy and mitophagy to Alzheimer's disease pathology. · 7/10 · Genomics/Precision Medicine — Nature Aging 2026, 40+ multinational authors incl. Zetterberg H ⚪
- TR-2026-05-15-008 / PMID 42135708 · ADL/IADL disability and all-cause mortality: evidence from 5 major longitudinal studies. · 7/10 · Public Health 🟡
Rare Diseases
→ No high-priority finds today. Best candidate scored 3/10 (case report). All 10 candidates reviewed were case reports, protocol publications, or out-of-scope articles.
💡 UNSOLICITED FINDS
None above threshold today. BLOODTRACC (42135686) was captured by both the sentinel scan and watchlist topics; it is classified as a watchlist hit.
📊 TODAY'S BREAKDOWN
By research category:
- Early Detection: 2 (TR-001 HIGH, TR-003)
- Diagnostics: 6 (TR-003, TR-007, TR-010, TR-011, TR-013, TR-015)
- Treatment Innovation: 4 (TR-002, TR-006, TR-009, TR-012)
- Drug Development: 2 (TR-002, TR-016)
- Public Health: 3 (TR-005, TR-008)
- Prevention: 2 (TR-008, TR-009, TR-014)
- Genomics/Precision Medicine: 2 (TR-004, TR-014)
By evidence maturity:
- Exploratory: 11
- Validated: 4 (TR-001, TR-003, TR-005, TR-007, TR-008)
- Potentially Practice-Changing: 0
By watchlist topic (reviewed / kept / highest score):
| Topic | Reviewed | Kept | High Score |
|---|---|---|---|
| Hematologic malignancies | 10 | 1 | 5 |
| CBC/ML hematology | 10 | 3 | 9 |
| Early cancer detection | 10 | 3 | 9 |
| AI/ML diagnostics | 10 | 5 | 7 |
| Precision oncology | 10 | 3 | 7 |
| Immunotherapy/CAR-T | 10 | 3 | 5 |
| CV-metabolic/GLP-1/SGLT2 | 10 | 3 | 7 |
| Aging/longevity | 10 | 2 | 7 |
| Rare diseases | 10 | 0 | 3 |
| Sentinel scan | 10 | 1 | 9 |
By source type: peer_reviewed 16 | preprint 0
Topics with zero 8+ articles this run: Hematologic malignancies · Rare diseases · AI/ML diagnostics · Precision oncology · CV-metabolic · Aging
(Note: BLOODTRACC scores 9 and covers both CBC/ML and Early cancer detection; immunotherapy topic produced 1 HIGH via NOVEL_TREATMENT flag, not score threshold)
🔧 RUN NOTES
⚠️ Query construction deviation: Aging/longevity topic — humans[MeSH] filter was NOT applied this run. Per task prompt note (added after 2026-05-04 run), this filter is required to reduce non-human/pest biology noise. Results appeared to be human-relevant today (Nat Aging, BMC Geriatr journals), but filter must be restored next run.
Partial coverage: ~89 unique PMIDs reviewed across topics. Approximately 20–30 additional candidate PMIDs in the CRDT window were not fully summarized due to esummary API truncation (responses capped at 20,000 chars). Higher-numbered PMIDs (42135719–42135827 range) received partial title coverage only. This is acceptable for daily incremental triage.
Window: Standard 24-hour CRDT window. No expansion triggered (16 relevant articles identified before expansion threshold of <5 would apply).
Sentinel scan: 597 total results. No unsolicited finds outside watchlist topics. BLOODTRACC captured via both CBC/ML and early detection topics.
Rare diseases rolling pattern: Zero STANDARD+ articles from rare disease topic for 3rd run in a row. May benefit from narrower/more specific query targeting (e.g., specific rare hematologic disorders).
Today vs. yesterday: 2 HIGH articles today vs. 0 on 2026-05-14. Standout finds: BLOODTRACC (CBC/CRC detection validation, 9/10) and Betrixaban/cGAS-STING (NOVEL_TREATMENT, FDA-approved drug repurposing).