Management and predictors of ICU admission in DRESS: A multicentre retrospective cohort study
Hospital-acquired DRESS and disease severity predict ICU admission in this rare condition, helping doctors identify high-risk patients early.
This 39-center retrospective cohort study identifies hospital-acquired DRESS and disease severity as the primary determinants of ICU admission (17% overall rate) in hospitalized DRESS patients, with 20% ICU mortality. These risk stratification findings can guide early triage and resource allocation for this rare but potentially life-threatening drug hypersensitivity syndrome.
What the study was
- Study design
- Multicentre retrospective cohort study (39 Paris-area centers, health data warehouse)
- Population
- Adult patients with probable/definite DRESS (RegiSCAR score ≥4) hospitalized in Greater Paris area, Jul 2017-Jan 2023; n=207
- Sample size
- 207
- Category
- Diagnostics
- Maturity
- Validated
- Journal
- Journal of the European Academy of Dermatology and Venereology
Why it surfaced
Largest multi-center study of DRESS ICU predictors to date (n=207, 39 centers). Rare but potentially fatal drug reaction with 20% ICU mortality. Actionable risk stratification criteria identified. Surfaced via sentinel.
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