Cancer and Immune Cells: A Metabolic Battle in the Tumor Microenvironment.
Understanding how tumors starve immune cells of fuel suggests combining drugs that restore immune cell energy with existing cancer immunotherapies.
A review chapter synthesizing the metabolic competition between cancer cells and immune effectors in the tumor microenvironment, identifying CAR-T and checkpoint inhibitor efficacy limitations driven by TME-induced metabolic suppression. The chapter proposes a therapeutic framework integrating metabolic intervention (e.g., targeting lactate, oxidative phosphorylation) with immunotherapy.
What the study was
- Study design
- Narrative review (book chapter)
- Category
- Treatment Innovation
- Maturity
- Exploratory
- Journal
- Cancer Treatment and Research
Why it surfaced
Useful background on immunometabolism in TME but book chapter review with no new primary data; limited triage utility.
A plain-language summary of published research — not medical advice. Talk to a clinician about your own care.