Hypertension, Dyslipidemia, and Adhesive Capsulitis: A Bidirectional Two-Sample Mendelian Randomization Study of the European Population.
Genetic analysis suggests shoulder stiffness may drive cholesterol changes rather than the reverse, shifting focus for prevention and treatment strategies.
Bidirectional Mendelian randomization using GWAS data found no causal effect of hypertension or dyslipidemia on adhesive capsulitis, but identified a significant reverse causal effect of AC on HDL and apoB/A1 ratio. These findings challenge observational associations and suggest adhesive capsulitis may be a driver rather than a consequence of lipid dysregulation.
What the study was
- Study design
- Bidirectional two-sample Mendelian randomization + case-control study
- Population
- European ancestry GWAS cohorts; hospital-based case-control (200 AC patients, 200 controls)
- Sample size
- 400
- Category
- Public Health
- Maturity
- Exploratory
- Journal
- Genetics Research (Cambridge)
Why it surfaced
Interesting MR methodology but topic (adhesive capsulitis/lipids) is outside watchlist; flagged as unsolicited find from sentinel scan.
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