Post-Chornobyl thyroid papillary carcinomas display distinct past 131I exposure and radiation-associated carcinogenesis molecular signatures at low and high thyroid doses
Multi-omic analysis distinguished radiation exposure signatures from cancer-driving changes in post-Chornobyl thyroid tumors, clarifying screening detection patterns.
Using sPLS-DA multi-omic analysis of 49 Ukrainian samples, this study dissected exposure history vs. carcinogenesis-specific molecular signatures in post-Chornobyl thyroid papillary carcinomas, identifying 83 radiation-specific genes/miRNAs as exposure markers and 103 as radiation-carcinogenesis markers. Low-dose exposed PTCs appear largely subclinical tumors revealed by screening, while high-dose PTCs exhibit distinct molecular deviation from sporadic PTC.
What the study was
- Study design
- Multi-omic molecular study (miRNome + RNA-seq, multiblock sPLS-DA)
- Population
- Ukrainian individuals exposed to Chornobyl 131I (high: >0.5 Gy n=9, low: <50 mGy n=12) and unexposed controls (n=28)
- Sample size
- 49
- Category
- Genomics/Precision Medicine
- Maturity
- Exploratory
- Journal
- Scientific Reports
Why it surfaced
Methodologically innovative multi-omic dissection of radiation carcinogenesis; small sample sizes (n=9-28 per group) limit conclusions. Sci Rep. Public health radiation-exposure relevance.
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