Tumor-Platelet Crosstalk in Cancer: Mechanisms, Thrombotic Risk, and Translational Opportunities
Blood platelets contain cancer-related RNA signals that may complement existing liquid biopsies for earlier cancer detection and monitoring alongside current blood tests.
This review synthesizes the bidirectional crosstalk between tumors and platelets, covering immune evasion, metastatic facilitation, and cancer-associated thrombosis mechanisms, with emerging platelet liquid biopsy and antiplatelet therapeutic angles. Platelet RNA profiling for cancer detection and classification represents a novel liquid biopsy modality complementary to ctDNA approaches.
What the study was
- Study design
- Narrative review
- Population
- N/A (review of tumor-platelet biology and cancer-associated thrombosis)
- Category
- Early Detection
- Maturity
- Exploratory
- Journal
- Blood Advances
Why it surfaced
Blood Advances review; NYU group; novel liquid biopsy angle (platelet RNA) complementary to ctDNA; cancer-associated thrombosis prevention is an unmet need.
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