Exome-wide association study of blood lipids in 1,158,017 individuals from diverse populations.
Analyzing genetic variants in over 1.1 million diverse people reveals new cardiovascular risk factors, helping doctors better predict and prevent heart disease across different populations.
This exome-wide association study—the largest of its kind for blood lipids—analyzes coding variants in 1,158,017 individuals from diverse ancestries to map genetic determinants of lipid traits. The scale and diversity make this a landmark resource for identifying novel therapeutic targets and refining cardiovascular risk stratification across populations.
What the study was
- Study design
- Exome-wide association study (ExWAS)
- Population
- 1,158,017 individuals from diverse populations (including VA Million Veteran Program and major international cohorts)
- Sample size
- 1158017
- Category
- Genomics/Precision Medicine
- Maturity
- Validated
- Journal
- Nature Genetics
Why it surfaced
Landmark Nature Genetics ExWAS with n=1.16M diverse individuals — largest lipid genomics study to date, directly identifies drug targets and improves cardiovascular risk prediction across ancestries.
A plain-language summary of published research — not medical advice. Talk to a clinician about your own care.