Single-cell eQTL-based Mendelian randomization identifies immune cell subtype-specific regulators of epigenetic aging and prioritizes candidate therapeutic targets.
Researchers pinpoint immune-cell-specific genes that control aging markers, narrowing down potential targets for future anti-aging therapies.
Using single-cell eQTL data integrated with Mendelian randomization, this study identifies immune cell subtype-specific genetic factors that causally regulate epigenetic aging biomarkers. The findings prioritize specific molecular targets that could be leveraged for anti-aging interventions.
What the study was
- Study design
- Mendelian randomization using single-cell eQTL data
- Population
- Human immune cell subtypes; population-level genetic data
- Category
- Genomics/Precision Medicine
- Maturity
- Exploratory
- Journal
- Biogerontology
Why it surfaced
Novel methodological intersection of single-cell genomics and causal inference for aging research; identifies actionable therapeutic targets for longevity.
A plain-language summary of published research — not medical advice. Talk to a clinician about your own care.