Technical recommendations from a large-scale French Delphi consensus: A step toward European harmonization of ctDNA analysis
Detailed technical standards from high-volume labs harmonize blood cancer DNA testing across Europe, reducing false results and improving reliability.
A Delphi consensus involving 39 French high-volume ctDNA platforms produced 37 technical recommendations with ≥80% agreement covering the full ctDNA analysis workflow, including mandatory UMI implementation, double centrifugation, CHIP evaluation protocols, and comprehensive reporting requirements. These complement existing international guidelines with operationally prescriptive guidance to reduce inter-laboratory variability and enable European ctDNA harmonization.
What the study was
- Study design
- Delphi consensus process
- Population
- 39 high-volume French molecular oncology platforms (71% response rate)
- Sample size
- 39
- Category
- Diagnostics
- Maturity
- Validated
- Journal
- European Journal of Cancer
Why it surfaced
Largest European ctDNA technical consensus to date (39 platforms); addresses real-world reproducibility gaps critical for ctDNA clinical adoption; practical EU harmonization framework; Eur J Cancer publication
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