Mapping the neurovascular landscape in aging and dementia: cerebral small vessel disease markers in a multicenter Latin American cohort
Latin American research reveals hypertension and smoking drive the most dementia-related brain changes, informing targeted prevention strategies for underrepresented populations.
The first large-scale multicenter Latin American study of cerebral small vessel disease in 1,675 participants across 6 countries demonstrated that Alzheimer's disease carries the greatest CSVD burden, with hypertension and smoking as the strongest modifiable correlates of white matter hyperintensities. These findings address a critical evidence gap in underrepresented populations with distinct cardiometabolic risk profiles and inform region-specific dementia prevention strategies.
What the study was
- Study design
- Multicenter cross-sectional cohort
- Population
- 1675 participants from 6 Latin American countries (790 healthy controls, 642 AD, 243 FTD)
- Sample size
- 1675
- Category
- Prevention
- Maturity
- Validated
- Journal
- Alzheimer's & Dementia
Why it surfaced
First large Latin American CSVD dementia cohort (n=1,675; 6 countries); addresses significant evidence gap in underrepresented populations; Alzheimer's & Dementia flagship journal; cardiometabolic-aging crossover relevance
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