vanA-consistent phenotype vancomycin-resistant enterococcal colonization is associated with inferior overall survival in acute myeloid leukemia patients undergoing intensive chemotherapy: a single-center retrospective study.
VRE bacteria phenotyping in leukemia patients may predict survival, offering doctors another factor to guide treatment and infection management decisions.
In 192 VRE-colonized AML patients at Goethe-University Frankfurt, the minority with vanA-consistent (teicoplanin-resistant) VRE phenotype had significantly inferior overall survival versus those with vanB-consistent phenotype on multivariate Cox regression, independent of ELN 2022 genetic risk. This suggests VRE phenotyping (vanA vs vanB) during AML induction may have prognostic value and could guide antimicrobial management decisions.
What the study was
- Study design
- Retrospective single-center cohort
- Population
- VRE-colonized AML patients undergoing intensive induction chemotherapy, 2015-2024 (n=192)
- Sample size
- 192
- Category
- Treatment Innovation
- Maturity
- Exploratory
- Journal
- Infection
Why it surfaced
Novel finding distinguishing VRE phenotypes in AML outcomes; practical implication for antimicrobial surveillance in hematology units. Single-center, retrospective, n=192 limits power.
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