Expanding roles of cGAS-STING signaling in neuroinflammation
Immune pathway dysregulation drives neuroinflammation and brain aging in Alzheimer's disease, with existing drugs ready for testing.
This JCI review synthesizes the rapidly expanding evidence that cGAS-STING pathway dysregulation is a central driver of neuroinflammation and brain aging, covering canonical innate immune activation and new noncanonical roles in chromatin organization and RNA metabolism. Current pharmacological inhibitors targeting cGAS and STING are catalogued, providing an actionable roadmap for therapeutic targeting in AD and related neurological disorders.
What the study was
- Study design
- Narrative review
- Category
- Treatment Innovation
- Maturity
- Exploratory
- Journal
- Journal of Clinical Investigation
Why it surfaced
High-quality JCI review on a therapeutically relevant pathway in neuroinflammation and brain aging; useful context for downstream pipeline even without new primary data.
A plain-language summary of published research — not medical advice. Talk to a clinician about your own care.