[18F]PSMA-3Q PET/CT radiomics at 45% SUVmax threshold: predicting post-surgical ISUP grade ≥4 and extraprostatic extension for noninvasive stratification in prostate cancer management
Advanced imaging analysis can predict which prostate cancers are more likely aggressive before surgery, helping guide personalized treatment planning.
A multi-algorithm radiomics analysis of 243 prostate cancer PET/CT scans identifies the 45% SUVmax threshold as optimal for predicting high-grade disease and extraprostatic extension, with AUC of 0.917, outperforming PET-only or clinical-only approaches. Findings support potential preoperative precision stratification of prostate cancer, pending larger multicenter external validation.
What the study was
- Study design
- Retrospective; n=243 prostate cancer patients (training n=190, test n=53); 9 ML algorithms; train/test split chronological; evaluation of AUC, sensitivity, specificity
- Population
- Prostate cancer patients undergoing [18F]PSMA-3Q PET/CT before radical prostatectomy
- Sample size
- 243
- Category
- Diagnostics
- Maturity
- Exploratory
- Journal
- Cancer Imaging
Why it surfaced
Novel [18F]PSMA-3Q PET/CT radiomics model with competitive AUC (0.917) for preoperative prostate cancer grading. Score limited by modest sample size (n=243) and lack of external multicenter validation.
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