Circular RNA serves as an upstream regulator of the miRNA//ABCC1 axis in human cancers
Circular RNA patterns linked to drug resistance offer new leads for liquid biopsy biomarkers, opening avenues to personalize cancer treatment.
This review in Pharmacology & Therapeutics comprehensively maps circRNA-mediated regulation of ABCC1/MRP1 multidrug resistance across multiple cancer types, identifying specific axes amenable to therapeutic targeting. CircRNAs are highlighted as promising liquid biopsy biomarkers due to their stability, with computational interaction prediction emerging as an enabling tool.
What the study was
- Study design
- Narrative review
- Category
- Drug Development
- Maturity
- Exploratory
- Journal
- Pharmacology & Therapeutics
Why it surfaced
Mechanistic review on MDR reversal mechanisms with liquid biopsy relevance. Published in high-impact Pharmacology & Therapeutics. Review design limits score; pre-clinical focus.
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