Gasdermin proteins as pyroptosis-based biomarkers in ovarian cancer: Diagnostic and prognostic utility
Gasdermin proteins in blood show potential as early detection markers for ovarian cancer, though they need rigorous validation before clinical use.
This review proposes gasdermin proteins as emerging liquid biopsy biomarkers for ovarian cancer, demonstrating tissue and circulating expression patterns that could complement established markers. It outlines validation requirements including multicenter analytical validation, commutable reference materials, and decision-impact studies needed before clinical translation.
What the study was
- Study design
- Narrative review
- Population
- Ovarian cancer patients (circulating and tissue biomarker data)
- Category
- Early Detection
- Maturity
- Exploratory
- Journal
- Clinica Chimica Acta
Why it surfaced
Novel biomarker class with liquid biopsy applicability in gynecologic cancer. Review format and lack of prospective validation data limits score.
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