Associations between multiple metabolic indices and circadian syndrome: a cross-sectional study with mediation analysis of the C-reactive protein triglyceride glucose index.
Inflammatory markers and metabolic measures interact to influence circadian rhythm disruption, suggesting new targets for prevention research.
This large cross-sectional study (n=6507) identifies significant non-linear associations between multiple metabolic indices and circadian syndrome, with the CRP-triglyceride glucose index (CTI) showing patterns consistent with mediation (20.8-86.5% of total effect). The findings support a 'metabolic-inflammatory axis' contributing to circadian syndrome but require prospective confirmation.
What the study was
- Study design
- Cross-sectional study with mediation analysis; CHARLS 2015 wave
- Population
- Chinese adults aged ≥45 years from the China Health and Retirement Longitudinal Study (CHARLS 2015)
- Sample size
- 6507
- Category
- Prevention
- Maturity
- Exploratory
- Journal
- Hormones (Athens)
Why it surfaced
Large Chinese cohort study (n=6507) on circadian syndrome and multiple metabolic markers. Hypothesis-generating cross-sectional design limits clinical applicability; mediation analysis provides mechanistic clues. Score limited by cross-sectional design and Chinese-specific population (CHARLS).
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