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‹ Wed · 10 Jun 2026
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Atypical Cutaneous Manifestation Leading to the Diagnosis of Chronic Lymphocytic Leukemia

Unusual skin lesions with severe blood counts warrant blood cancer screening via flow cytometry.

A 64-year-old male presenting with progressive ulcerating skin lesions, marked leukocytosis, and lymphadenopathy was diagnosed with CLL via peripheral flow cytometry, with skin biopsy confirming leukemia cutis. This case emphasizes the importance of evaluating unexplained cutaneous lesions with significant leukocytosis for hematologic malignancy.

What the study was

Study design
Single case report
Population
Single patient with CLL presenting as leukemia cutis
Sample size
1
Category
Diagnostics
Maturity
Exploratory
Journal
Cureus

Why it surfaced

Single case report (CLL leukemia cutis). Cureus publication. Score capped at 4 per rubric; scored 1 given minimal novelty in well-described presentation.

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