Bridging aging and colorectal cancer: synergistic roles of inflammaging and immunosenescence
Age-related inflammation and weakened immunity drive colorectal cancer growth in older adults, opening doors to prevention strategies tailored to aging biology.
This review synthesizes mechanistic evidence linking age-related chronic inflammation (inflammaging) and declining immune function (immunosenescence) to colorectal cancer pathogenesis, with implications for biomarker discovery and targeted prevention strategies in the elderly. It frames aging as a biological driver of CRC susceptibility rather than merely a risk factor.
What the study was
- Study design
- Narrative review
- Category
- Prevention
- Maturity
- Exploratory
- Journal
- Frontiers in Immunology
Why it surfaced
Mechanistic review bridging aging biology and colorectal cancer; relevant to aging/longevity and precision oncology watchlist topics. Review-level evidence only.
A plain-language summary of published research — not medical advice. Talk to a clinician about your own care.