📅 PUBMED DAILY TRIAGE — 2026-06-12

Window: 2026-06-11T09:00Z → 2026-06-12T09:00Z (CRDT) Topics scanned: 10 | Articles reviewed: ~35 | Candidates evaluated: ~35 High priority: 0 | Standard: 17 | Low/archive: 5 | Unsolicited finds: 0 Run status: SUCCESS

🔴🟠 HIGH PRIORITY (8+) — Best Finds by Topic

No HIGH-priority articles today (score ≥8 not reached). Best overall: 7/10.

Topic summary for HIGH threshold:

• CBC-based diagnostics / ML: No high-priority finds (best candidate scored 7/10)
• Cardiovascular-metabolic / GLP-1: No high-priority finds (best candidate scored 7/10)
• Rare diseases: No high-priority finds (best candidate scored 7/10)
• Hematologic malignancies: No high-priority finds (best candidate scored 6/10)
• Novel therapeutics / CAR-T: No high-priority finds (best candidate scored 6/10)
• Liquid biopsy / ctDNA: No high-priority finds (best candidate scored 5/10)
• AI/ML diagnostics: No high-priority finds (best candidate scored 5/10)
• Precision oncology: No high-priority finds (best candidate scored 5/10)
• Aging / longevity: No high-priority finds (best candidate scored 4/10)
• Sentinel scan: No additional unsolicited finds beyond watchlist topics

🟢⚪ STANDARD (5–7) — Top by Topic

CBC-based diagnostics and ML in hematology

• TR-2026-06-12-001 · PMID 42275170 · WBC count modifies treatment response to cefepime vs pip-tazo (AJRCCM) · 7/10 · Diagnostics
• TR-2026-06-12-008 · PMID 42272271 · Multicenter pediatric extreme leukocytosis 5-year study (n=125,471) (Pediatr Emerg Care) · 6/10 · Diagnostics

Cardiovascular-metabolic: GLP-1, SGLT2, cardiometabolic risk

• TR-2026-06-12-002 · PMID 42273973 · Semaglutide MASLD/MASH meta-analysis (n=1908, 10 studies) (Br J Clin Pharmacol) · 7/10 · Treatment Innovation

Rare diseases with high unmet need

• TR-2026-06-12-003 · PMID 42277127 · Circulating IGF2BP3 risk stratification in Ewing sarcoma (n=51) (Sci Rep) · 7/10 · Diagnostics / Rare Pediatric
• TR-2026-06-12-012 · PMID 42271415 · IMD caregiver burden family impacts, Canada (n=71 caregivers) (Orphanet J Rare Dis) · 5/10 · Public Health

Hematologic malignancies (AML, MDS, CLL, MPN, lymphoma)

• TR-2026-06-12-004 · PMID 42275539 · AML older adults pilot RCT UR-GOAL functional prognosis discordance (n=77) (Blood Advances) · 6/10 · Treatment Innovation
• TR-2026-06-12-005 · PMID 42271269 · AML therapy-induced senescence biomarker: p16/SASP predict OS/EFS (n=128) (BMC Cancer) · 6/10 · Genomics/Precision Medicine
• TR-2026-06-12-015 · PMID 42276140 · MPN coagulation disorders guide: ET/PV/PMF hemostatic complications (Hamostaseologie) · 4/10 · Diagnostics

Novel therapeutics: immunotherapy, CAR-T, targeted therapy

• TR-2026-06-12-006 · PMID 42274870 · CAR-T infectious complications: mechanisms, risk stratification, prevention (guideline-aligned review) (Blood Res) · 6/10 · Treatment Innovation
• TR-2026-06-12-007 · PMID 42272870 · NF2 vestibular schwannoma T-cell immunotherapy: TME spatial transcriptomics review (Brain Commun) · 6/10 · Treatment Innovation

Early cancer detection: liquid biopsy, ctDNA, cfDNA

• TR-2026-06-12-009 · PMID 42271643 · dd-cfDNA AlloSeq vs GraftAssure concordance, kidney transplant (n=254) (Clin Chem) · 5/10 · Diagnostics
• TR-2026-06-12-013 · PMID 42272923 · Nanotechnology platforms for cancer sensing/imaging: cfDNA, ctDNA, EVs (Nano Today) · 5/10 · Early Detection

AI/ML in clinical diagnostics and imaging

• TR-2026-06-12-010 · PMID 42275394 · Vision-language foundation models in clinical AI: applications and challenges (PLOS Digital Health) · 5/10 · Diagnostics

Precision oncology and genomic medicine

• TR-2026-06-12-011 · PMID 42273671 · Inflammaging/immunosenescence bridge to colorectal cancer: mechanistic review (Front Immunol) · 5/10 · Prevention
• TR-2026-06-12-014 · PMID 42274600 · Host-tumor metabolic crosstalk as driver of therapy resistance: integrative review (Cells) · 5/10 · Genomics/Precision Medicine

Aging, longevity, and population health

• TR-2026-06-12-016 · PMID 42276623 · Redox bioenergetics and neuronal senescence in Alzheimer's disease (Int Rev Neurobiol) · 4/10 · Other
• TR-2026-06-12-017 · PMID 42274608 · ZONAB regulates endothelial DNA methylation and senescence via mitochondrial pathway (Cells) · 4/10 · Genomics/Precision Medicine

💡 UNSOLICITED FINDS

None today. Sentinel scan (1087 raw, top-10 reviewed) — all high-signal candidates were already captured by watchlist queries.

📊 TODAY'S BREAKDOWN

By research category:

• Diagnostics: 6 articles
• Treatment Innovation: 5 articles
• Genomics/Precision Medicine: 3 articles
• Prevention: 1 article
• Public Health: 1 article
• Early Detection: 1 article

By evidence maturity:

• Validated: 4 (PMID 42275170, 42273973, 42271643, 42276140, 42274870)
• Exploratory: 12
• Potentially Practice-Changing: 0

By watchlist topic (reviewed/kept/highest score):

By source type:

• Peer reviewed: 17
• Preprint: 0

Topics with zero 8+ articles this run: ALL (no HIGH-priority articles today)

🔧 RUN NOTES

1. T2 CBC/ML — ZERO STREAK BROKEN: After 8 consecutive days with zero results, the pivot query (broadened to include predictive/clinical blood count usage) succeeded. First article (PMID 42275170, AJRCCM) is the strongest T2 result in weeks — WBC count as a treatment-response modifier for antibiotic choice in sepsis, derived from the ACORN RCT. Recommend maintaining this broader query while monitoring for ML-specific CBC articles.

2. T3 Liquid biopsy — Topic drift: Top results today were dominated by transplant-related cfDNA (kidney transplant assay comparison, face transplant rodent model), not cancer-specific ctDNA. Core cancer liquid biopsy articles may be in the remaining 9 unreviewed records beyond the top-3 sample. Recommend investigating the remaining T3 IDs (42277247, 42274209, 42277406, 42277396, 42276503, 42276999) in the next run or as a supplemental fetch.

3. T8 Aging/longevity — Query note: The strict humans[MeSH] NOT (fish OR rat OR mouse OR mice OR drosophila OR worm OR insect) filter successfully eliminated non-human noise (only 2 raw results, both human-relevant). However, yield is now very low. Consider relaxing slightly to include primary research papers without the full animal exclusion list, or expanding the window to 48h for this topic.

4. T9 Rare diseases: Three articles (42276024, 42274988, 42274032) were not retrieved within the per-run cap and are deferred. Recommend fetching in next run's incremental window.

5. No HIGH-priority articles (score ≥8) found today. Today was a moderate signal day; no Telegram alerts sent. This is unusual given typically 3–5 HIGH articles per run. Possible explanation: Friday publication cadence (many journals have lower new-article indexing on late-week CRDT dates).

6. Rolling 7-day view (from state): Topics consistently producing zero 8+ articles across recent days: T8 (Aging/longevity) — low yield with strict filter; T2 (CBC/ML) — resolved today; T4 (AI/ML) — predominantly review articles scoring ≤5.